Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2062268..2062782 Replicon chromosome
Accession NZ_CP117238
Organism Staphylococcus aureus strain ATCC 23235

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag PQQ27_RS10280 Protein ID WP_000581792.1
Coordinates 2062268..2062477 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag PQQ27_RS10285 Protein ID WP_000138932.1
Coordinates 2062489..2062782 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ27_RS10260 (PQQ27_10260) 2057776..2059134 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
PQQ27_RS10265 (PQQ27_10265) 2059149..2060219 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
PQQ27_RS10270 (PQQ27_10270) 2060537..2061739 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
PQQ27_RS10275 (PQQ27_10275) 2062003..2062140 - 138 WP_000828354.1 Lmo0850 family protein -
PQQ27_RS10280 (PQQ27_10280) 2062268..2062477 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
PQQ27_RS10285 (PQQ27_10285) 2062489..2062782 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
PQQ27_RS10290 (PQQ27_10290) 2062948..2064432 + 1485 WP_000571549.1 cardiolipin synthase -
PQQ27_RS10295 (PQQ27_10295) 2064460..2065107 + 648 WP_001187630.1 HD domain-containing protein -
PQQ27_RS10300 (PQQ27_10300) 2066020..2066892 - 873 WP_000725802.1 membrane protein insertase YidC -
PQQ27_RS10305 (PQQ27_10305) 2066978..2067619 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T270150 WP_000581792.1 NZ_CP117238:c2062477-2062268 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT270150 WP_000138932.1 NZ_CP117238:c2062782-2062489 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References