Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2052221..2052839 Replicon chromosome
Accession NC_017564
Organism Yersinia enterocolitica subsp. palearctica Y11

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag Y11_RS09565 Protein ID WP_002208622.1
Coordinates 2052636..2052839 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7U7FKE5
Locus tag Y11_RS09560 Protein ID WP_005163463.1
Coordinates 2052221..2052589 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y11_RS09530 2047875..2048135 + 261 WP_005163438.1 type B 50S ribosomal protein L31 -
Y11_RS09535 2048151..2048294 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
Y11_RS09540 2048422..2049300 - 879 WP_005163442.1 metal ABC transporter substrate-binding protein -
Y11_RS09545 2049363..2050220 - 858 WP_005163445.1 metal ABC transporter permease -
Y11_RS09550 2050234..2050944 - 711 WP_014609124.1 ABC transporter ATP-binding protein -
Y11_RS09555 2051710..2052063 + 354 WP_005163460.1 hypothetical protein -
Y11_RS09560 2052221..2052589 + 369 WP_005163463.1 Hha toxicity modulator TomB Antitoxin
Y11_RS09565 2052636..2052839 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
Y11_RS09570 2053676..2053981 + 306 WP_005163466.1 MGMT family protein -
Y11_RS09575 2054033..2054563 - 531 WP_005163468.1 YbaY family lipoprotein -
Y11_RS09580 2054824..2055687 + 864 WP_005163474.1 acyl-CoA thioesterase II -
Y11_RS09585 2055801..2057090 - 1290 WP_005167660.1 ammonium transporter AmtB -
Y11_RS09590 2057130..2057468 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2041820..2052839 11019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T27015 WP_002208622.1 NC_017564:2052636-2052839 [Yersinia enterocolitica subsp. palearctica Y11]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T27015 NC_017564:2052636-2052839 [Yersinia enterocolitica subsp. palearctica Y11]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTGGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGACGATGAGCTGGAATTGTTTTACTCAGCAGCAGACCACCGCTTAGCTGAACTCACAATGAATAAAC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14192.90 Da        Isoelectric Point: 4.3377

>AT27015 WP_005163463.1 NC_017564:2052221-2052589 [Yersinia enterocolitica subsp. palearctica Y11]
MDEYSPKRHDVAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELQRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp

>AT27015 NC_017564:2052221-2052589 [Yersinia enterocolitica subsp. palearctica Y11]
ATGGATGAGTACTCACCTAAGCGGCATGACGTTGCCCAATTGAAGTTCCTGTGCGAGAGTTTGTATGATGAAGGCATTGC
TACCCTTGGTGATAGCCATCATGGCTGGGTAAATGATCCAACTTCAGCCGTAAACCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGACGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTACGGAATCAATGATCCGGAATTGCAGCGCTGGCAAAAAACTAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACCCTGATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
PDB 2MN2
AlphaFold DB A0A7U7FKE5

References