Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2041009..2041538 Replicon chromosome
Accession NZ_CP117238
Organism Staphylococcus aureus strain ATCC 23235

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PQQ27_RS10180 Protein ID WP_000621175.1
Coordinates 2041009..2041371 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag PQQ27_RS10185 Protein ID WP_000948331.1
Coordinates 2041368..2041538 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ27_RS10160 (PQQ27_10160) 2037987..2038757 - 771 WP_001041111.1 RNA polymerase sigma factor SigB -
PQQ27_RS10165 (PQQ27_10165) 2038732..2039211 - 480 WP_001190829.1 anti-sigma B factor RsbW -
PQQ27_RS10170 (PQQ27_10170) 2039213..2039539 - 327 WP_001052796.1 anti-sigma factor antagonist -
PQQ27_RS10175 (PQQ27_10175) 2039658..2040659 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
PQQ27_RS10180 (PQQ27_10180) 2041009..2041371 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PQQ27_RS10185 (PQQ27_10185) 2041368..2041538 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PQQ27_RS10190 (PQQ27_10190) 2041623..2042771 - 1149 WP_001281153.1 alanine racemase -
PQQ27_RS10195 (PQQ27_10195) 2042837..2043196 - 360 WP_000581197.1 holo-ACP synthase -
PQQ27_RS10200 (PQQ27_10200) 2043200..2043691 - 492 WP_001205912.1 PH domain-containing protein -
PQQ27_RS10205 (PQQ27_10205) 2043678..2045261 - 1584 WP_001294626.1 PH domain-containing protein -
PQQ27_RS10210 (PQQ27_10210) 2045254..2045733 - 480 WP_001287087.1 hypothetical protein -
PQQ27_RS10215 (PQQ27_10215) 2045941..2046501 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T270149 WP_000621175.1 NZ_CP117238:c2041371-2041009 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT270149 WP_000948331.1 NZ_CP117238:c2041538-2041368 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References