Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1887786..1888562 Replicon chromosome
Accession NZ_CP117238
Organism Staphylococcus aureus strain ATCC 23235

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag PQQ27_RS09290 Protein ID WP_000031108.1
Coordinates 1887786..1887938 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag PQQ27_RS09295 Protein ID WP_001251224.1
Coordinates 1887963..1888562 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ27_RS09275 (PQQ27_09275) 1883988..1884809 + 822 WP_000669376.1 RluA family pseudouridine synthase -
PQQ27_RS09280 (PQQ27_09280) 1885262..1886647 - 1386 WP_000116228.1 class II fumarate hydratase -
PQQ27_RS09285 (PQQ27_09285) 1886843..1887238 - 396 WP_000901023.1 hypothetical protein -
PQQ27_RS09290 (PQQ27_09290) 1887786..1887938 - 153 WP_000031108.1 SAS053 family protein Toxin
PQQ27_RS09295 (PQQ27_09295) 1887963..1888562 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
PQQ27_RS09300 (PQQ27_09300) 1888721..1889191 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
PQQ27_RS09305 (PQQ27_09305) 1889196..1890323 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
PQQ27_RS09310 (PQQ27_09310) 1890474..1891196 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
PQQ27_RS09315 (PQQ27_09315) 1891189..1892646 - 1458 WP_000649914.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T270148 WP_000031108.1 NZ_CP117238:c1887938-1887786 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT270148 WP_001251224.1 NZ_CP117238:c1888562-1887963 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References