Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4608042..4608539 Replicon chromosome
Accession NZ_CP117235
Organism Escherichia coli strain ATCC 25922

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag PQQ28_RS22715 Protein ID WP_001173343.1
Coordinates 4608042..4608215 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag PQQ28_RS22720 Protein ID WP_001312331.1
Coordinates 4608243..4608539 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ28_RS22705 (4604712) 4604712..4606169 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
PQQ28_RS22710 (4606406) 4606406..4607923 + 1518 WP_000003806.1 lysine--tRNA ligase -
PQQ28_RS22715 (4608042) 4608042..4608215 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
PQQ28_RS22720 (4608243) 4608243..4608539 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PQQ28_RS22725 (4608768) 4608768..4609040 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
PQQ28_RS22730 (4609052) 4609052..4609282 - 231 WP_000371715.1 4Fe-4S mono-cluster protein YjdI -
PQQ28_RS22735 (4609463) 4609463..4611094 + 1632 WP_001216466.1 sensor histidine kinase -
PQQ28_RS22740 (4611091) 4611091..4611810 + 720 WP_000611291.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T270144 WP_001173343.1 NZ_CP117235:c4608215-4608042 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT270144 WP_001312331.1 NZ_CP117235:c4608539-4608243 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References