Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3738229..3738847 Replicon chromosome
Accession NZ_CP117235
Organism Escherichia coli strain ATCC 25922

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PQQ28_RS18540 Protein ID WP_001291435.1
Coordinates 3738629..3738847 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PQQ28_RS18535 Protein ID WP_000344800.1
Coordinates 3738229..3738603 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ28_RS18525 (3733319) 3733319..3734512 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQQ28_RS18530 (3734535) 3734535..3737684 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
PQQ28_RS18535 (3738229) 3738229..3738603 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PQQ28_RS18540 (3738629) 3738629..3738847 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PQQ28_RS18545 (3739020) 3739020..3739571 + 552 WP_000102539.1 maltose O-acetyltransferase -
PQQ28_RS18550 (3739687) 3739687..3740157 + 471 WP_001304825.1 YlaC family protein -
PQQ28_RS18555 (3740321) 3740321..3741871 + 1551 WP_001528761.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PQQ28_RS18560 (3741913) 3741913..3742266 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PQQ28_RS18570 (3742645) 3742645..3742956 + 312 WP_000409908.1 MGMT family protein -
PQQ28_RS18575 (3742987) 3742987..3743559 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T270138 WP_001291435.1 NZ_CP117235:3738629-3738847 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT270138 WP_000344800.1 NZ_CP117235:3738229-3738603 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References