Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2998494..2998965 Replicon chromosome
Accession NZ_CP117235
Organism Escherichia coli strain ATCC 25922

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag PQQ28_RS14960 Protein ID WP_001303511.1
Coordinates 2998687..2998965 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag PQQ28_RS14955 Protein ID WP_001302048.1
Coordinates 2998494..2998685 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ28_RS14910 (2993743) 2993743..2993961 - 219 WP_000209148.1 DUF4014 family protein -
PQQ28_RS14915 (2993994) 2993994..2994206 - 213 WP_000072553.1 hypothetical protein -
PQQ28_RS14920 (2994312) 2994312..2994734 - 423 Protein_2855 DUF977 family protein -
PQQ28_RS14925 (2994750) 2994750..2995520 - 771 WP_000450998.1 DUF1627 domain-containing protein -
PQQ28_RS14930 (2995542) 2995542..2996288 - 747 WP_000788950.1 ATP-binding protein -
PQQ28_RS14935 (2996295) 2996295..2997257 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
PQQ28_RS14940 (2997280) 2997280..2997705 - 426 WP_000693943.1 toxin YdaT family protein -
PQQ28_RS14945 (2997702) 2997702..2998004 - 303 WP_001556930.1 transcriptional regulator -
PQQ28_RS14950 (2998102) 2998102..2998473 + 372 WP_001169687.1 hypothetical protein -
PQQ28_RS14955 (2998494) 2998494..2998685 + 192 WP_001302048.1 hypothetical protein Antitoxin
PQQ28_RS14960 (2998687) 2998687..2998965 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ28_RS14965 (2999257) 2999257..2999409 + 153 WP_000380313.1 DUF1391 family protein -
PQQ28_RS14970 (2999421) 2999421..2999759 + 339 WP_000394541.1 hypothetical protein -
PQQ28_RS14975 (2999748) 2999748..2999942 - 195 WP_001295058.1 hypothetical protein -
PQQ28_RS14980 (3000518) 3000518..3000706 + 189 WP_000449175.1 cell division inhibition protein DicB -
PQQ28_RS14985 (3000703) 3000703..3000891 + 189 WP_000199475.1 DUF1482 family protein -
PQQ28_RS14990 (3000984) 3000984..3003422 + 2439 WP_000102132.1 exonuclease -
PQQ28_RS14995 (3003484) 3003484..3003753 + 270 WP_000003742.1 excisionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2981097..3008148 27051
- inside Prophage sitABCD - 2867824..3012008 144184


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T270136 WP_001303511.1 NZ_CP117235:2998687-2998965 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT270136 WP_001302048.1 NZ_CP117235:2998494-2998685 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References