Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 997559..998213 Replicon chromosome
Accession NZ_CP117235
Organism Escherichia coli strain ATCC 25922

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag PQQ28_RS05320 Protein ID WP_000244781.1
Coordinates 997806..998213 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PQQ28_RS05315 Protein ID WP_000354046.1
Coordinates 997559..997825 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ28_RS05295 (993647) 993647..995080 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
PQQ28_RS05300 (995125) 995125..995436 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
PQQ28_RS05305 (995600) 995600..996259 + 660 WP_000250274.1 hemolysin III family protein -
PQQ28_RS05310 (996336) 996336..997316 - 981 WP_000886079.1 tRNA-modifying protein YgfZ -
PQQ28_RS05315 (997559) 997559..997825 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PQQ28_RS05320 (997806) 997806..998213 + 408 WP_000244781.1 protein YgfX Toxin
PQQ28_RS05325 (998253) 998253..998774 - 522 WP_001055874.1 flavodoxin FldB -
PQQ28_RS05330 (998886) 998886..999782 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PQQ28_RS05335 (999807) 999807..1000517 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQQ28_RS05340 (1000523) 1000523..1002256 + 1734 WP_000813189.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T270126 WP_000244781.1 NZ_CP117235:997806-998213 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT270126 WP_000354046.1 NZ_CP117235:997559-997825 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References