Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2118096..2118610 Replicon chromosome
Accession NZ_CP117230
Organism Staphylococcus aureus strain ATCC 25923

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag PQQ26_RS10480 Protein ID WP_000581791.1
Coordinates 2118096..2118305 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag PQQ26_RS10485 Protein ID WP_000138934.1
Coordinates 2118317..2118610 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ26_RS10460 (PQQ26_10460) 2113985..2115055 - 1071 WP_000159638.1 D-alanine--D-alanine ligase -
PQQ26_RS10465 (PQQ26_10465) 2115373..2116575 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
PQQ26_RS10470 (PQQ26_10470) 2116736..2117419 - 684 Protein_2024 transposase -
PQQ26_RS10475 (PQQ26_10475) 2117831..2117968 - 138 WP_000828354.1 Lmo0850 family protein -
PQQ26_RS10480 (PQQ26_10480) 2118096..2118305 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
PQQ26_RS10485 (PQQ26_10485) 2118317..2118610 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
PQQ26_RS10490 (PQQ26_10490) 2118776..2120260 + 1485 WP_000571560.1 cardiolipin synthase -
PQQ26_RS10495 (PQQ26_10495) 2120288..2120935 + 648 WP_001187612.1 HD domain-containing protein -
PQQ26_RS10500 (PQQ26_10500) 2121092..2121391 + 300 WP_001793952.1 hypothetical protein -
PQQ26_RS10505 (PQQ26_10505) 2121548..2122420 - 873 WP_000725802.1 membrane protein insertase YidC -
PQQ26_RS10510 (PQQ26_10510) 2122506..2123147 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T270118 WP_000581791.1 NZ_CP117230:c2118305-2118096 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT270118 WP_000138934.1 NZ_CP117230:c2118610-2118317 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References