Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1929456..1930232 Replicon chromosome
Accession NZ_CP117230
Organism Staphylococcus aureus strain ATCC 25923

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag PQQ26_RS09390 Protein ID WP_000031108.1
Coordinates 1929456..1929608 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag PQQ26_RS09395 Protein ID WP_001251219.1
Coordinates 1929633..1930232 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ26_RS09375 (PQQ26_09375) 1925603..1926424 + 822 WP_000669380.1 RluA family pseudouridine synthase -
PQQ26_RS09380 (PQQ26_09380) 1926879..1928264 - 1386 WP_000116227.1 class II fumarate hydratase -
PQQ26_RS09385 (PQQ26_09385) 1928460..1928855 - 396 WP_000901019.1 hypothetical protein -
PQQ26_RS09390 (PQQ26_09390) 1929456..1929608 - 153 WP_000031108.1 SAS053 family protein Toxin
PQQ26_RS09395 (PQQ26_09395) 1929633..1930232 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
PQQ26_RS09400 (PQQ26_09400) 1930391..1930861 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
PQQ26_RS09405 (PQQ26_09405) 1930866..1931993 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
PQQ26_RS09410 (PQQ26_09410) 1932144..1932866 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
PQQ26_RS09415 (PQQ26_09415) 1932859..1934316 - 1458 WP_000649898.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T270115 WP_000031108.1 NZ_CP117230:c1929608-1929456 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT270115 WP_001251219.1 NZ_CP117230:c1930232-1929633 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References