270111

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 864059..864688 Replicon chromosome
Accession NZ_CP117229
Organism Listeria innocua strain ATCC 33090

Toxin (Protein)


Gene name pemK Uniprot ID Q92DC7
Locus tag PQQ29_RS04765 Protein ID WP_010990666.1
Coordinates 864341..864688 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID H1GC21
Locus tag PQQ29_RS04760 Protein ID WP_003761302.1
Coordinates 864059..864337 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ29_RS04740 (PQQ29_04740) 859356..860840 + 1485 WP_187984061.1 PH domain-containing protein -
PQQ29_RS04745 (PQQ29_04745) 860991..862370 + 1380 WP_070753404.1 protoporphyrinogen oxidase -
PQQ29_RS04750 (PQQ29_04750) 862372..862728 + 357 WP_003761296.1 holo-ACP synthase -
PQQ29_RS04755 (PQQ29_04755) 862747..863853 + 1107 WP_187984062.1 alanine racemase -
PQQ29_RS04760 (PQQ29_04760) 864059..864337 + 279 WP_003761302.1 CopG family ribbon-helix-helix protein Antitoxin
PQQ29_RS04765 (PQQ29_04765) 864341..864688 + 348 WP_010990666.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PQQ29_RS04770 (PQQ29_04770) 864940..865776 + 837 WP_003771126.1 STAS domain-containing protein -
PQQ29_RS04775 (PQQ29_04775) 865782..866138 + 357 WP_187984063.1 STAS domain-containing protein -
PQQ29_RS04780 (PQQ29_04780) 866141..866551 + 411 WP_010990667.1 anti-sigma regulatory factor -
PQQ29_RS04785 (PQQ29_04785) 866568..867572 + 1005 WP_045553450.1 PP2C family protein-serine/threonine phosphatase -
PQQ29_RS04790 (PQQ29_04790) 867722..868066 + 345 WP_187997213.1 anti sigma b factor antagonist RsbV -
PQQ29_RS04795 (PQQ29_04795) 868050..868523 + 474 WP_003761314.1 anti-sigma B factor RsbW -
PQQ29_RS04800 (PQQ29_04800) 868501..869280 + 780 WP_010990669.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12801.85 Da        Isoelectric Point: 6.4735

>T270111 WP_010990666.1 NZ_CP117229:864341-864688 [Listeria innocua]
MMVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIR
TIDKQRLTDKITHLDEELMAKVNQALEVSLGVVEF

Download         Length: 348 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10605.13 Da        Isoelectric Point: 4.2980

>AT270111 WP_003761302.1 NZ_CP117229:864059-864337 [Listeria innocua]
VLEKEKRMIISVELTQEMVQELDVVVEKEKMGRSEVIMEATQQFLQEKRARELRDEMERGYAEMATINFAIACECTHVEA
EAEDRNISILGG

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E7E4N0

Antitoxin

Source ID Structure
AlphaFold DB H1GC21

References