Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5030493..5032174 Replicon chromosome
Accession NZ_CP117227
Organism Klebsiella pneumoniae strain ATCC BAA2146

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag PQQ24_RS27020 Protein ID WP_002885155.1
Coordinates 5030493..5031410 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag PQQ24_RS27025 Protein ID WP_004151732.1
Coordinates 5031416..5032174 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ24_RS27000 (PQQ24_27000) 5025799..5027319 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
PQQ24_RS27005 (PQQ24_27005) 5027316..5028314 + 999 WP_002885172.1 ribose ABC transporter permease -
PQQ24_RS27010 (PQQ24_27010) 5028345..5029286 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
PQQ24_RS27015 (PQQ24_27015) 5029361..5030368 + 1008 WP_004151731.1 carbohydrate kinase family protein -
PQQ24_RS27020 (PQQ24_27020) 5030493..5031410 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
PQQ24_RS27025 (PQQ24_27025) 5031416..5032174 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
PQQ24_RS27030 (PQQ24_27030) 5032260..5032988 - 729 WP_002885152.1 response regulator transcription factor -
PQQ24_RS27035 (PQQ24_27035) 5033261..5035408 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
PQQ24_RS27040 (PQQ24_27040) 5035638..5036324 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T270108 WP_002885155.1 NZ_CP117227:c5031410-5030493 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT270108 WP_004151732.1 NZ_CP117227:c5032174-5031416 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References