Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4874453..4874969 Replicon chromosome
Accession NZ_CP117227
Organism Klebsiella pneumoniae strain ATCC BAA2146

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag PQQ24_RS26225 Protein ID WP_002886902.1
Coordinates 4874453..4874737 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag PQQ24_RS26230 Protein ID WP_002886901.1
Coordinates 4874727..4874969 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ24_RS26200 (PQQ24_26200) 4869937..4870200 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
PQQ24_RS26205 (PQQ24_26205) 4870330..4870503 + 174 WP_002886906.1 hypothetical protein -
PQQ24_RS26210 (PQQ24_26210) 4870506..4871249 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
PQQ24_RS26215 (PQQ24_26215) 4871606..4873744 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
PQQ24_RS26220 (PQQ24_26220) 4873985..4874449 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQQ24_RS26225 (PQQ24_26225) 4874453..4874737 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ24_RS26230 (PQQ24_26230) 4874727..4874969 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQQ24_RS26235 (PQQ24_26235) 4875047..4876957 - 1911 WP_004152270.1 PRD domain-containing protein -
PQQ24_RS26240 (PQQ24_26240) 4876980..4878134 - 1155 WP_002886900.1 lactonase family protein -
PQQ24_RS26245 (PQQ24_26245) 4878200..4878940 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T270107 WP_002886902.1 NZ_CP117227:c4874737-4874453 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT270107 WP_002886901.1 NZ_CP117227:c4874969-4874727 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References