Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2113456..2113970 Replicon chromosome
Accession NZ_CP117203
Organism Staphylococcus aureus strain 2022QW-00133

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag PQQ74_RS10455 Protein ID WP_000581792.1
Coordinates 2113456..2113665 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag PQQ74_RS10460 Protein ID WP_000138932.1
Coordinates 2113677..2113970 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ74_RS10435 (2108964) 2108964..2110322 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
PQQ74_RS10440 (2110337) 2110337..2111407 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
PQQ74_RS10445 (2111725) 2111725..2112927 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
PQQ74_RS10450 (2113191) 2113191..2113328 - 138 WP_000828354.1 Lmo0850 family protein -
PQQ74_RS10455 (2113456) 2113456..2113665 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
PQQ74_RS10460 (2113677) 2113677..2113970 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
PQQ74_RS10465 (2114136) 2114136..2115620 + 1485 WP_000571549.1 cardiolipin synthase -
PQQ74_RS10470 (2115648) 2115648..2116295 + 648 WP_001187629.1 HD domain-containing protein -
PQQ74_RS10475 (2117108) 2117108..2117980 - 873 WP_000725802.1 membrane protein insertase YidC -
PQQ74_RS10480 (2118066) 2118066..2118707 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T270088 WP_000581792.1 NZ_CP117203:c2113665-2113456 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT270088 WP_000138932.1 NZ_CP117203:c2113970-2113677 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References