Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2093700..2094229 Replicon chromosome
Accession NZ_CP117203
Organism Staphylococcus aureus strain 2022QW-00133

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PQQ74_RS10365 Protein ID WP_000621175.1
Coordinates 2093700..2094062 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag PQQ74_RS10370 Protein ID WP_000948331.1
Coordinates 2094059..2094229 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ74_RS10345 (2090679) 2090679..2091449 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
PQQ74_RS10350 (2091424) 2091424..2091903 - 480 WP_001190829.1 anti-sigma B factor RsbW -
PQQ74_RS10355 (2091905) 2091905..2092231 - 327 WP_001052491.1 anti-sigma factor antagonist -
PQQ74_RS10360 (2092350) 2092350..2093351 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
PQQ74_RS10365 (2093700) 2093700..2094062 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PQQ74_RS10370 (2094059) 2094059..2094229 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PQQ74_RS10375 (2094314) 2094314..2095462 - 1149 WP_001281145.1 alanine racemase -
PQQ74_RS10380 (2095528) 2095528..2095887 - 360 WP_000581200.1 holo-ACP synthase -
PQQ74_RS10385 (2095891) 2095891..2096382 - 492 WP_001205910.1 PH domain-containing protein -
PQQ74_RS10390 (2096369) 2096369..2097952 - 1584 WP_001294626.1 PH domain-containing protein -
PQQ74_RS10395 (2097945) 2097945..2098424 - 480 WP_001287088.1 hypothetical protein -
PQQ74_RS10400 (2098632) 2098632..2099192 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T270087 WP_000621175.1 NZ_CP117203:c2094062-2093700 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT270087 WP_000948331.1 NZ_CP117203:c2094229-2094059 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References