270083

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1893001..1893777 Replicon chromosome
Accession NZ_CP117203
Organism Staphylococcus aureus strain 2022QW-00133

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag PQQ74_RS09090 Protein ID WP_000031108.1
Coordinates 1893001..1893153 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag PQQ74_RS09095 Protein ID WP_001251224.1
Coordinates 1893178..1893777 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ74_RS09075 (1888964) 1888964..1889785 + 822 WP_000669376.1 RluA family pseudouridine synthase -
PQQ74_RS09080 (1890248) 1890248..1891633 - 1386 WP_000116224.1 class II fumarate hydratase -
PQQ74_RS09085 (1891829) 1891829..1892224 - 396 WP_000901021.1 hypothetical protein -
PQQ74_RS09090 (1893001) 1893001..1893153 - 153 WP_000031108.1 SAS053 family protein Toxin
PQQ74_RS09095 (1893178) 1893178..1893777 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
PQQ74_RS09100 (1893936) 1893936..1894406 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
PQQ74_RS09105 (1894411) 1894411..1895538 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
PQQ74_RS09110 (1895689) 1895689..1896412 - 724 Protein_1784 amino acid ABC transporter ATP-binding protein -
PQQ74_RS09115 (1896405) 1896405..1897862 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T270083 WP_000031108.1 NZ_CP117203:c1893153-1893001 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT270083 WP_001251224.1 NZ_CP117203:c1893777-1893178 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References