Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 23785..24815 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP117201 | ||
| Organism | Pantoea sp. SS70 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | PO881_RS23280 | Protein ID | WP_280173439.1 |
| Coordinates | 24240..24815 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | - |
| Locus tag | PO881_RS23275 | Protein ID | WP_280173438.1 |
| Coordinates | 23785..24243 (+) | Length | 153 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PO881_RS23235 (PO881_23235) | 18933..19175 | + | 243 | WP_280173431.1 | regulatory protein YcgZ | - |
| PO881_RS23240 (PO881_23240) | 19282..19554 | + | 273 | WP_280173432.1 | hypothetical protein | - |
| PO881_RS23245 (PO881_23245) | 20042..20239 | - | 198 | WP_280173433.1 | hypothetical protein | - |
| PO881_RS23250 (PO881_23250) | 20311..20571 | - | 261 | WP_280173434.1 | hypothetical protein | - |
| PO881_RS23255 (PO881_23255) | 21037..21309 | + | 273 | WP_280173435.1 | hypothetical protein | - |
| PO881_RS23260 (PO881_23260) | 21390..22550 | - | 1161 | WP_280173436.1 | diguanylate phosphodiesterase | - |
| PO881_RS23265 (PO881_23265) | 22791..23042 | + | 252 | WP_280173437.1 | antitoxin | - |
| PO881_RS23270 (PO881_23270) | 23039..23324 | + | 286 | Protein_25 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| PO881_RS23275 (PO881_23275) | 23785..24243 | + | 459 | WP_280173438.1 | helix-turn-helix domain-containing protein | Antitoxin |
| PO881_RS23280 (PO881_23280) | 24240..24815 | + | 576 | WP_280173439.1 | PIN domain-containing protein | Toxin |
| PO881_RS23285 (PO881_23285) | 24824..25858 | - | 1035 | WP_280173440.1 | tyrosine-type recombinase/integrase | - |
| PO881_RS23290 (PO881_23290) | 26720..27634 | + | 915 | WP_280173441.1 | hypothetical protein | - |
| PO881_RS23295 (PO881_23295) | 27679..28290 | + | 612 | WP_280173442.1 | hypothetical protein | - |
| PO881_RS23300 (PO881_23300) | 28722..29792 | - | 1071 | Protein_31 | alanine racemase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..196862 | 196862 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21655.90 Da Isoelectric Point: 5.6559
>T270079 WP_280173439.1 NZ_CP117201:24240-24815 [Pantoea sp. SS70]
MSSGYTVIFDACVLYPAPLRSFLMYLAAGGQFRARWTEDIHEEWIRNVLLNRTELNLAQLQRVRALMDRHVPDALVTGYQ
SLTDSIRGLPDKDDRHVVAAAIVARAEGIVTFNLKDFPDDVLATWNLRAIHPDSFITDLTELDITLVLDAARRQRASLKS
PPFTPDEFLDCLLRQQLPETVSRLRPLTALI
MSSGYTVIFDACVLYPAPLRSFLMYLAAGGQFRARWTEDIHEEWIRNVLLNRTELNLAQLQRVRALMDRHVPDALVTGYQ
SLTDSIRGLPDKDDRHVVAAAIVARAEGIVTFNLKDFPDDVLATWNLRAIHPDSFITDLTELDITLVLDAARRQRASLKS
PPFTPDEFLDCLLRQQLPETVSRLRPLTALI
Download Length: 576 bp
Antitoxin
Download Length: 153 a.a. Molecular weight: 17018.40 Da Isoelectric Point: 5.2831
>AT270079 WP_280173438.1 NZ_CP117201:23785-24243 [Pantoea sp. SS70]
MTQLQNKLPSLQEAELARLCSRELSAVLETRAESQQVSLTDRSGRIHNVSIPVSALRMLVDVLTELGDGNAVRLVPVGAE
MTTQEVADLLNISRPTLIRLLDNGELPYHRTGNRRKIRYMDALAYREKLVNQRHDALDELGALDQELGLGYE
MTQLQNKLPSLQEAELARLCSRELSAVLETRAESQQVSLTDRSGRIHNVSIPVSALRMLVDVLTELGDGNAVRLVPVGAE
MTTQEVADLLNISRPTLIRLLDNGELPYHRTGNRRKIRYMDALAYREKLVNQRHDALDELGALDQELGLGYE
Download Length: 459 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|