Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2626749..2627368 Replicon chromosome
Accession NZ_CP117199
Organism Pantoea sp. SS70

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PO881_RS12210 Protein ID WP_280171844.1
Coordinates 2627180..2627368 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PO881_RS12205 Protein ID WP_101763410.1
Coordinates 2626749..2627162 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO881_RS12185 (PO881_12185) 2622676..2623503 - 828 WP_192233450.1 MetQ/NlpA family lipoprotein -
PO881_RS12190 (PO881_12190) 2623718..2624359 + 642 WP_271460770.1 TetR family transcriptional regulator -
PO881_RS12195 (PO881_12195) 2624434..2625816 + 1383 WP_137386084.1 D-arabinono-1,4-lactone oxidase -
PO881_RS12200 (PO881_12200) 2625835..2626662 + 828 WP_061717669.1 glycosyltransferase family 8 protein -
PO881_RS12205 (PO881_12205) 2626749..2627162 - 414 WP_101763410.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PO881_RS12210 (PO881_12210) 2627180..2627368 - 189 WP_280171844.1 type II toxin-antitoxin system HicA family toxin Toxin
PO881_RS12215 (PO881_12215) 2627510..2627830 - 321 WP_008110563.1 PTS system regulator TmaR -
PO881_RS12220 (PO881_12220) 2627992..2629050 - 1059 WP_101763409.1 FUSC family protein -
PO881_RS12225 (PO881_12225) 2629359..2630525 - 1167 WP_192233442.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
PO881_RS12230 (PO881_12230) 2630728..2632149 + 1422 WP_110866679.1 exodeoxyribonuclease I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6985.20 Da        Isoelectric Point: 11.0007

>T270069 WP_280171844.1 NZ_CP117199:c2627368-2627180 [Pantoea sp. SS70]
MDSRSLMAEIKADGWELIRVNGSHHHFVHPVKKGLVTIPHPKKDLPIKTVKSNRKQAGLTVH

Download         Length: 189 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14914.23 Da        Isoelectric Point: 4.5951

>AT270069 WP_101763410.1 NZ_CP117199:c2627162-2626749 [Pantoea sp. SS70]
MFYPIAIEAGDQSTAFGVTVPDLPGCFSAGDTLEAAVTNAKEAIIGHLELLVELEQDIPAVSELKSLMKDPQYAGYVWVL
IDVDVTRILGGSEKINVTLPKLLIDRIDRCVATHPEFKTRSGFLAQVALERIAKTRS

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References