Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 389820..390513 Replicon chromosome
Accession NZ_CP117199
Organism Pantoea sp. SS70

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PO881_RS01740 Protein ID WP_222234556.1
Coordinates 389820..389996 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PO881_RS01745 Protein ID WP_101763040.1
Coordinates 390109..390513 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO881_RS01725 (PO881_01725) 385300..385626 - 327 WP_008109989.1 DUF485 domain-containing protein -
PO881_RS01730 (PO881_01730) 385773..387728 - 1956 WP_280172350.1 acetate--CoA ligase -
PO881_RS01735 (PO881_01735) 388310..389611 + 1302 WP_007888562.1 glutamate/aspartate:proton symporter GltP -
PO881_RS01740 (PO881_01740) 389820..389996 + 177 WP_222234556.1 type II toxin-antitoxin system HicA family toxin Toxin
PO881_RS01745 (PO881_01745) 390109..390513 + 405 WP_101763040.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PO881_RS01750 (PO881_01750) 390654..391565 + 912 WP_277974407.1 N-acetylmuramic acid 6-phosphate etherase -
PO881_RS01755 (PO881_01755) 391565..392995 + 1431 WP_101763038.1 PTS N-acetylmuramic acid transporter subunit IIBC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-55)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6863.13 Da        Isoelectric Point: 10.9513

>T270066 WP_222234556.1 NZ_CP117199:389820-389996 [Pantoea sp. SS70]
MSSRELIRMLLERGWVLDRVKGSHHVFVRRDKPYHISLPHPEKDLATGTVRKLIKLMD

Download         Length: 177 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14751.29 Da        Isoelectric Point: 4.4077

>AT270066 WP_101763040.1 NZ_CP117199:390109-390513 [Pantoea sp. SS70]
MRFPVYLHKTESNTYSGFVPDVVGCFFAGETVDDALTDASAAIDSHVESSTDAGYEVPVATNIETHIEDENCQGGYWAFV
DIDLSRYEGKAVKLNITLPQNLLTKIDSYVDHHREYGSRSGFLAALARKELANA

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References