Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 916648..917222 Replicon chromosome
Accession NZ_CP117196
Organism Pasteurella multocida strain P2237

Toxin (Protein)


Gene name PumA Uniprot ID A0A849CFF7
Locus tag M9D40_RS04370 Protein ID WP_014667974.1
Coordinates 916938..917222 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A849CG04
Locus tag M9D40_RS04365 Protein ID WP_014391174.1
Coordinates 916648..916941 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9D40_RS04345 (M9D40_004345) 911814..912905 - 1092 WP_005756839.1 L-ascorbate 6-phosphate lactonase -
M9D40_RS04350 (M9D40_004350) 913254..915044 + 1791 WP_014391171.1 PTS ascorbate-specific subunit IIBC -
M9D40_RS04355 (M9D40_004355) 915089..915556 + 468 WP_014391172.1 PTS sugar transporter subunit IIA -
M9D40_RS04360 (M9D40_004360) 915574..916251 + 678 WP_014391173.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
M9D40_RS04365 (M9D40_004365) 916648..916941 - 294 WP_014391174.1 putative addiction module antidote protein Antitoxin
M9D40_RS04370 (M9D40_004370) 916938..917222 - 285 WP_014667974.1 addiction module protein Toxin
M9D40_RS04380 (M9D40_004380) 918516..918777 - 262 Protein_837 hypothetical protein -
M9D40_RS04385 (M9D40_004385) 919121..919273 - 153 WP_014391177.1 hypothetical protein -
M9D40_RS04390 (M9D40_004390) 919573..921759 - 2187 WP_014667973.1 S8 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 918516..918677 161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-85)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10702.41 Da        Isoelectric Point: 10.2849

>T270061 WP_014667974.1 NZ_CP117196:c917222-916938 [Pasteurella multocida]
VGRLREVKNLSAKAAVLARINRVMNGNLGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.80 Da        Isoelectric Point: 8.9149

>AT270061 WP_014391174.1 NZ_CP117196:c916941-916648 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALADVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKITHSLGIKLVPTHI

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A849CFF7

Antitoxin

Source ID Structure
AlphaFold DB A0A849CG04

References