Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4585041..4585801 Replicon chromosome
Accession NZ_CP117184
Organism Salmonella enterica subsp. enterica strain 123

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag PQ453_RS22690 Protein ID WP_000533909.1
Coordinates 4585041..4585526 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag PQ453_RS22695 Protein ID WP_000965886.1
Coordinates 4585514..4585801 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQ453_RS22660 (4580111) 4580111..4580773 + 663 WP_000747548.1 OmpA family lipoprotein -
PQ453_RS22665 (4580992) 4580992..4581966 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
PQ453_RS22670 (4582016) 4582016..4582726 - 711 WP_000190524.1 DUF3053 domain-containing protein -
PQ453_RS22675 (4583165) 4583165..4583455 + 291 WP_000455790.1 HTH-type transcriptional regulator -
PQ453_RS22680 (4583744) 4583744..4583956 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PQ453_RS22685 (4584130) 4584130..4584669 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
PQ453_RS22690 (4585041) 4585041..4585526 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
PQ453_RS22695 (4585514) 4585514..4585801 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
PQ453_RS22700 (4585979) 4585979..4586446 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
PQ453_RS22705 (4586618) 4586618..4586893 - 276 Protein_4433 IS3 family transposase -
PQ453_RS22710 (4587075) 4587075..4589144 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
PQ453_RS22715 (4589154) 4589154..4590065 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
PQ453_RS22720 (4590204) 4590204..4590506 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T270055 WP_000533909.1 NZ_CP117184:c4585526-4585041 [Salmonella enterica subsp. enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT270055 WP_000965886.1 NZ_CP117184:c4585801-4585514 [Salmonella enterica subsp. enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References