Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3872716..3873376 Replicon chromosome
Accession NZ_CP117184
Organism Salmonella enterica subsp. enterica strain 123

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag PQ453_RS19175 Protein ID WP_000244756.1
Coordinates 3872716..3873129 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQ453_RS19180 Protein ID WP_000351186.1
Coordinates 3873110..3873376 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQ453_RS19155 (3868657) 3868657..3870390 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
PQ453_RS19160 (3870396) 3870396..3871109 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQ453_RS19165 (3871133) 3871133..3872029 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PQ453_RS19170 (3872142) 3872142..3872663 + 522 WP_001055885.1 flavodoxin FldB -
PQ453_RS19175 (3872716) 3872716..3873129 - 414 WP_000244756.1 protein YgfX Toxin
PQ453_RS19180 (3873110) 3873110..3873376 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQ453_RS19185 (3873626) 3873626..3874606 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
PQ453_RS19190 (3874722) 3874722..3875381 - 660 WP_000250289.1 hemolysin III family protein -
PQ453_RS19195 (3875545) 3875545..3875856 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
PQ453_RS19200 (3876015) 3876015..3877448 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T270052 WP_000244756.1 NZ_CP117184:c3873129-3872716 [Salmonella enterica subsp. enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270052 WP_000351186.1 NZ_CP117184:c3873376-3873110 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References