Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3444741..3445358 Replicon chromosome
Accession NC_017554
Organism Pantoea ananatis PA13

Toxin (Protein)


Gene name Hha Uniprot ID D4GLR0
Locus tag PAGR_RS16370 Protein ID WP_013024903.1
Coordinates 3445143..3445358 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag PAGR_RS16365 Protein ID WP_014606431.1
Coordinates 3444741..3445118 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAGR_RS16335 3441025..3441279 + 255 WP_014606427.1 type B 50S ribosomal protein L31 -
PAGR_RS16340 3441291..3441431 + 141 WP_014606428.1 type B 50S ribosomal protein L36 -
PAGR_RS16345 3441491..3442369 - 879 WP_013024908.1 metal ABC transporter substrate-binding protein -
PAGR_RS16350 3442382..3443221 - 840 WP_013024907.1 metal ABC transporter permease -
PAGR_RS16355 3443218..3443886 - 669 WP_014606429.1 ABC transporter ATP-binding protein -
PAGR_RS16360 3444241..3444594 + 354 WP_014606430.1 hypothetical protein -
PAGR_RS16365 3444741..3445118 + 378 WP_014606431.1 Hha toxicity modulator TomB Antitoxin
PAGR_RS16370 3445143..3445358 + 216 WP_013024903.1 hemolysin expression modulator Hha Toxin
PAGR_RS16375 3445756..3446067 + 312 WP_014606432.1 MGMT family protein -
PAGR_RS16380 3446116..3446673 - 558 WP_014606433.1 YbaY family lipoprotein -
PAGR_RS16385 3446866..3447729 + 864 WP_014606434.1 acyl-CoA thioesterase II -
PAGR_RS16390 3447776..3449065 - 1290 WP_014606435.1 ammonium transporter AmtB -
PAGR_RS16395 3449100..3449438 - 339 WP_013024898.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8552.98 Da        Isoelectric Point: 9.4825

>T27005 WP_013024903.1 NC_017554:3445143-3445358 [Pantoea ananatis PA13]
MNKTLTKTDYLMRLRRCRSIDTLERVIEKNKYELPDEELAVFYSAADHRLAELTMNKLYDKVPVSVWKFVR

Download         Length: 216 bp

>T27005 NC_017554:3445143-3445358 [Pantoea ananatis PA13]
ATGAACAAAACCCTAACTAAAACTGATTATTTGATGCGACTGAGGCGCTGTCGCTCTATTGACACGCTGGAACGCGTGAT
TGAAAAAAATAAGTACGAATTACCCGATGAAGAATTAGCAGTATTTTACTCAGCAGCCGATCACCGCCTGGCTGAACTGA
CGATGAACAAGCTCTATGACAAAGTCCCGGTGTCAGTCTGGAAATTTGTACGCTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14695.32 Da        Isoelectric Point: 4.3976

>AT27005 WP_014606431.1 NC_017554:3444741-3445118 [Pantoea ananatis PA13]
MDEYSPKRHDIAQLKYLCESLFDDSMATLTDSHHGWVNDPTAESNLQLNDLIEHIASFTMNYKIKHVEDEALITQIDEYL
DDTFMLFSNYSVNTQDLQRWQRSAKRLFNVFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT27005 NC_017554:3444741-3445118 [Pantoea ananatis PA13]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATACTTGTGTGAGAGTCTGTTTGACGACAGCATGGC
GACATTAACTGACAGTCATCATGGCTGGGTTAATGACCCCACTGCCGAAAGCAACTTACAGCTAAACGATTTGATTGAGC
ACATCGCCTCTTTCACCATGAATTACAAAATTAAGCACGTTGAAGACGAAGCACTGATTACCCAAATCGATGAATATCTT
GATGATACCTTTATGCTGTTTAGCAACTACAGTGTAAATACTCAGGATCTTCAGCGCTGGCAACGCTCAGCGAAACGTTT
ATTTAATGTGTTTACTGAAGAGTGCGCTTTTCTTCAACAGCCAAGCCATTCATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References