270045

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2289732..2290254 Replicon chromosome
Accession NZ_CP117184
Organism Salmonella enterica subsp. enterica strain 123

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag PQ453_RS11300 Protein ID WP_000221343.1
Coordinates 2289732..2290016 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQ453_RS11305 Protein ID WP_000885424.1
Coordinates 2290006..2290254 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQ453_RS11280 (2285807) 2285807..2287315 - 1509 WP_000199411.1 FAD-dependent oxidoreductase -
PQ453_RS11285 (2287360) 2287360..2287848 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PQ453_RS11290 (2288041) 2288041..2289120 + 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQ453_RS11295 (2289172) 2289172..2289561 - 390 WP_000194089.1 RidA family protein -
PQ453_RS11300 (2289732) 2289732..2290016 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQ453_RS11305 (2290006) 2290006..2290254 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQ453_RS11310 (2290406) 2290406..2290621 + 216 WP_000206207.1 hypothetical protein -
PQ453_RS11315 (2290611) 2290611..2290943 + 333 WP_000253154.1 DUF1493 family protein -
PQ453_RS11320 (2291086) 2291086..2291994 + 909 WP_010989018.1 hypothetical protein -
PQ453_RS11325 (2292050) 2292050..2292764 - 715 Protein_2208 helix-turn-helix domain-containing protein -
PQ453_RS11330 (2293572) 2293572..2295038 - 1467 WP_000987828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T270045 WP_000221343.1 NZ_CP117184:c2290016-2289732 [Salmonella enterica subsp. enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT270045 WP_000885424.1 NZ_CP117184:c2290254-2290006 [Salmonella enterica subsp. enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References