Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1241553..1242173 Replicon chromosome
Accession NZ_CP117184
Organism Salmonella enterica subsp. enterica strain 123

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQ453_RS06025 Protein ID WP_001280991.1
Coordinates 1241553..1241771 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQ453_RS06030 Protein ID WP_000344807.1
Coordinates 1241799..1242173 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQ453_RS05985 (1236777) 1236777..1237346 + 570 WP_000779803.1 YbaY family lipoprotein -
PQ453_RS05990 (1237379) 1237379..1237768 - 390 WP_000961285.1 MGMT family protein -
PQ453_RS06000 (1237999) 1237999..1239549 - 1551 WP_000213139.1 EAL domain-containing protein -
PQ453_RS06005 (1239774) 1239774..1240034 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQ453_RS06010 (1240040) 1240040..1240180 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQ453_RS06015 (1240236) 1240236..1240706 - 471 WP_000136181.1 YlaC family protein -
PQ453_RS06020 (1240823) 1240823..1241374 - 552 WP_001278792.1 maltose O-acetyltransferase -
PQ453_RS06025 (1241553) 1241553..1241771 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PQ453_RS06030 (1241799) 1241799..1242173 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQ453_RS06035 (1242669) 1242669..1245818 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQ453_RS06040 (1245841) 1245841..1247034 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270044 WP_001280991.1 NZ_CP117184:c1241771-1241553 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270044 WP_000344807.1 NZ_CP117184:c1242173-1241799 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References