270038

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1291884..1292801 Replicon chromosome
Accession NZ_CP117182
Organism Bacillus velezensis strain Lwp6

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag PO767_RS06810 Protein ID WP_007407256.1
Coordinates 1292055..1292801 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag PO767_RS06805 Protein ID WP_003154807.1
Coordinates 1291884..1292054 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO767_RS06765 (1287117) 1287117..1288739 + 1623 WP_022553476.1 pyocin knob domain-containing protein -
PO767_RS06770 (1288752) 1288752..1289123 + 372 WP_022553475.1 XkdW family protein -
PO767_RS06775 (1289128) 1289128..1289325 + 198 WP_007610833.1 XkdX family protein -
PO767_RS06780 (1289382) 1289382..1290143 + 762 WP_022553474.1 hypothetical protein -
PO767_RS06785 (1290195) 1290195..1290458 + 264 WP_022553473.1 hemolysin XhlA family protein -
PO767_RS06790 (1290472) 1290472..1290735 + 264 WP_003154813.1 phage holin -
PO767_RS06795 (1290749) 1290749..1291627 + 879 WP_007407257.1 N-acetylmuramoyl-L-alanine amidase -
PO767_RS06800 (1291662) 1291662..1291787 - 126 WP_003154809.1 hypothetical protein -
PO767_RS06805 (1291884) 1291884..1292054 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
PO767_RS06810 (1292055) 1292055..1292801 - 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
PO767_RS06815 (1292906) 1292906..1293904 - 999 WP_003154805.1 inorganic phosphate transporter -
PO767_RS06820 (1293917) 1293917..1294534 - 618 WP_003154804.1 DUF47 domain-containing protein -
PO767_RS06825 (1294820) 1294820..1296136 - 1317 WP_007610842.1 amino acid permease -
PO767_RS06830 (1296458) 1296458..1297408 + 951 WP_022553472.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1258174..1339373 81199


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T270038 WP_007407256.1 NZ_CP117182:c1292801-1292055 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT270038 WP_003154807.1 NZ_CP117182:c1292054-1291884 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References