270036

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 4108080..4108602 Replicon chromosome
Accession NZ_CP117181
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28S

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag PQP75_RS19860 Protein ID WP_000221345.1
Coordinates 4108318..4108602 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQP75_RS19855 Protein ID WP_000885424.1
Coordinates 4108080..4108328 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP75_RS19825 (4103623) 4103623..4104403 + 781 Protein_3855 helix-turn-helix domain-containing protein -
PQP75_RS19830 (4104405) 4104405..4105313 - 909 WP_077906523.1 hypothetical protein -
PQP75_RS19835 (4105586) 4105586..4105918 - 333 WP_017441352.1 DUF1493 family protein -
PQP75_RS19840 (4106441) 4106441..4106557 - 117 Protein_3858 IS110 family transposase -
PQP75_RS19845 (4106922) 4106922..4107311 + 390 WP_017441353.1 hypothetical protein -
PQP75_RS19850 (4107314) 4107314..4107667 + 354 WP_000418733.1 hypothetical protein -
PQP75_RS19855 (4108080) 4108080..4108328 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQP75_RS19860 (4108318) 4108318..4108602 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP75_RS19865 (4108773) 4108773..4109162 + 390 WP_001652798.1 RidA family protein -
PQP75_RS19870 (4109220) 4109220..4110293 - 1074 WP_017441355.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQP75_RS19875 (4110486) 4110486..4110974 - 489 WP_017441356.1 MarR family winged helix-turn-helix transcriptional regulator -
PQP75_RS19880 (4111019) 4111019..4112527 + 1509 WP_017441357.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4098874..4115384 16510


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T270036 WP_000221345.1 NZ_CP117181:4108318-4108602 [Salmonella enterica subsp. enterica serovar Mbandaka]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT270036 WP_000885424.1 NZ_CP117181:4108080-4108328 [Salmonella enterica subsp. enterica serovar Mbandaka]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References