Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2750016..2750830 Replicon chromosome
Accession NZ_CP117181
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28S

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3W0Q3Z8
Locus tag PQP75_RS13245 Protein ID WP_017441137.1
Coordinates 2750016..2750543 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A418Z520
Locus tag PQP75_RS13250 Protein ID WP_017441138.1
Coordinates 2750540..2750830 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP75_RS13215 (2746389) 2746389..2746787 + 399 Protein_2563 cytoplasmic protein -
PQP75_RS13220 (2746978) 2746978..2747217 + 240 Protein_2564 hypothetical protein -
PQP75_RS13225 (2747374) 2747374..2748042 + 669 WP_000445914.1 hypothetical protein -
PQP75_RS13230 (2748069) 2748069..2748563 + 495 WP_000424947.1 hypothetical protein -
PQP75_RS13235 (2748734) 2748734..2749390 - 657 WP_017441135.1 protein-serine/threonine phosphatase -
PQP75_RS13240 (2749728) 2749728..2749943 + 216 Protein_2568 IS5/IS1182 family transposase -
PQP75_RS13245 (2750016) 2750016..2750543 - 528 WP_017441137.1 GNAT family N-acetyltransferase Toxin
PQP75_RS13250 (2750540) 2750540..2750830 - 291 WP_017441138.1 DUF1778 domain-containing protein Antitoxin
PQP75_RS13255 (2751100) 2751100..2751300 - 201 Protein_2571 IS3 family transposase -
PQP75_RS13260 (2751541) 2751541..2751867 + 327 WP_000393295.1 hypothetical protein -
PQP75_RS13265 (2752140) 2752140..2752487 - 348 WP_001555786.1 DUF1493 family protein -
PQP75_RS13270 (2752472) 2752472..2752921 - 450 WP_017441139.1 hypothetical protein -
PQP75_RS13275 (2753353) 2753353..2753796 - 444 WP_017441140.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PQP75_RS13280 (2754252) 2754252..2754902 + 651 WP_001728903.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 2749803..2760215 10412
- flank IS/Tn - - 2749803..2749943 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19035.89 Da        Isoelectric Point: 9.6420

>T270030 WP_017441137.1 NZ_CP117181:c2750543-2750016 [Salmonella enterica subsp. enterica serovar Mbandaka]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SLKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10721.55 Da        Isoelectric Point: 8.5957

>AT270030 WP_017441138.1 NZ_CP117181:c2750830-2750540 [Salmonella enterica subsp. enterica serovar Mbandaka]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFARPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W0Q3Z8

Antitoxin

Source ID Structure
AlphaFold DB A0A418Z520

References