Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2338570..2339918 Replicon chromosome
Accession NC_017554
Organism Pantoea ananatis PA13

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PAGR_RS11035 Protein ID WP_014605802.1
Coordinates 2338809..2339918 (+) Length 370 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PAGR_RS11030 Protein ID WP_014605801.1
Coordinates 2338570..2338809 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAGR_RS11015 2334162..2335550 + 1389 WP_014605798.1 MFS transporter -
PAGR_RS11020 2335573..2337948 + 2376 WP_014605799.1 glycoside hydrolase family 3 C-terminal domain-containing protein -
PAGR_RS11025 2338012..2338455 - 444 WP_014605800.1 GNAT family N-acetyltransferase -
PAGR_RS11030 2338570..2338809 + 240 WP_014605801.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PAGR_RS11035 2338809..2339918 + 1110 WP_014605802.1 HipA domain-containing protein Toxin
PAGR_RS11040 2339964..2340380 - 417 WP_014605803.1 GFA family protein -
PAGR_RS11050 2340834..2342702 - 1869 WP_013025825.1 low affinity potassium transporter Kup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-55)


Sequences

Toxin        


Download         Length: 370 a.a.        Molecular weight: 40921.24 Da        Isoelectric Point: 7.4551

>T27003 WP_014605802.1 NC_017554:2338809-2339918 [Pantoea ananatis PA13]
MAKLIAWINGERTGTLTLHHNGALHFQYDANWLQHPLARPLSLSLPLQRAAMHSEKVVHFFENLLYPSALIEKDFYPTHP
IKSCEVFATLQKVGHTLPGALSLLPAKRQPVAPDQATHSIFTPADEAQQFDIDNAYLCLSLARELTIPVPDAVLVHENGI
RKLRTERYDRRWRHDGQHLYHLPEEDVCQALGVPLSGRDEQQGGPGIDDIMALLMGSSSAMKDREDLMRCLVFQWLTGIT
RVNAKHLSLLIARGGSFRLAPFKHLLSACPGLSLRTTDRRDFQLGMGLTGPEGKQHHIDAIGPAHFLALAGSVGFSQAAM
RQILAAFIPGLPAAIIKVRDSLPDDYPLTLADAVFSHAMMMLERVRQAT

Download         Length: 1110 bp

>T27003 NC_017554:2338809-2339918 [Pantoea ananatis PA13]
ATGGCAAAGCTCATTGCCTGGATAAACGGCGAGCGTACGGGAACGCTGACGCTGCATCACAACGGCGCGCTGCATTTCCA
GTATGACGCCAACTGGCTTCAGCATCCGCTTGCCAGACCTCTCTCGCTTTCGTTGCCCTTACAGCGCGCCGCGATGCATT
CTGAGAAAGTCGTGCACTTTTTCGAAAACCTTCTCTATCCCAGCGCGTTGATCGAAAAGGATTTTTACCCGACTCACCCG
ATAAAATCCTGTGAGGTCTTTGCAACATTGCAGAAAGTGGGACACACATTACCCGGGGCGCTCAGTCTGCTGCCGGCAAA
GCGGCAGCCCGTCGCGCCGGACCAGGCAACGCACAGCATCTTCACCCCCGCCGATGAGGCACAGCAGTTCGATATCGATA
ATGCGTATCTGTGTCTGTCCCTGGCCCGGGAGCTGACTATCCCGGTGCCGGATGCCGTATTAGTTCATGAGAACGGCATC
CGTAAATTGAGAACAGAACGATACGATCGCCGTTGGCGTCACGACGGACAACACCTTTATCATCTTCCTGAAGAAGACGT
GTGTCAGGCGCTCGGCGTGCCGCTCTCTGGCCGCGATGAGCAGCAGGGCGGTCCGGGAATTGATGACATCATGGCCTTGC
TGATGGGCTCAAGCTCCGCCATGAAAGACCGTGAGGATCTGATGCGCTGTCTGGTATTTCAGTGGCTGACGGGCATCACG
CGCGTCAACGCTAAACATCTCTCGCTGCTGATTGCTCGCGGTGGCAGCTTCCGGCTCGCGCCTTTTAAGCATCTCCTTTC
CGCCTGCCCGGGCCTTTCTCTACGCACAACAGACAGACGGGATTTCCAGCTGGGGATGGGCCTGACAGGCCCTGAGGGCA
AACAGCATCACATTGACGCGATTGGGCCCGCGCATTTTCTTGCCCTTGCGGGGAGCGTGGGGTTCAGTCAGGCAGCGATG
CGGCAGATACTGGCGGCCTTTATTCCGGGCTTGCCTGCCGCGATTATTAAGGTGCGGGACAGCCTGCCCGATGATTATCC
CCTGACGCTCGCCGATGCGGTTTTCAGCCACGCAATGATGATGCTGGAAAGGGTGCGCCAGGCGACCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8773.03 Da        Isoelectric Point: 7.2012

>AT27003 WP_014605801.1 NC_017554:2338570-2338809 [Pantoea ananatis PA13]
MIYSPRQLANQVRLLRQQNGWTQVELAKKVGLKQATLSHFENAPDTTSLATLFKILQALDLALLLHENSASSAPAEDAW

Download         Length: 240 bp

>AT27003 NC_017554:2338570-2338809 [Pantoea ananatis PA13]
ATGATTTACAGTCCCCGCCAGTTGGCAAATCAGGTCAGGCTACTGCGGCAGCAAAACGGCTGGACCCAGGTCGAACTGGC
GAAAAAAGTGGGCCTGAAACAGGCAACCCTGTCTCACTTCGAAAATGCCCCGGATACAACCTCACTGGCAACGTTGTTCA
AAATCTTACAGGCGCTCGATCTTGCTCTGTTGCTTCATGAAAACAGCGCATCCTCAGCCCCGGCTGAGGATGCCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References