Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2592060..2592720 Replicon chromosome
Accession NZ_CP117181
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28S

Toxin (Protein)


Gene name cptA Uniprot ID A0A3V4SJP5
Locus tag PQP75_RS12525 Protein ID WP_000244755.1
Coordinates 2592307..2592720 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQP75_RS12520 Protein ID WP_000351186.1
Coordinates 2592060..2592326 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP75_RS12500 (2587989) 2587989..2589422 - 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -
PQP75_RS12505 (2589580) 2589580..2589891 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
PQP75_RS12510 (2590055) 2590055..2590714 + 660 WP_000250289.1 hemolysin III family protein -
PQP75_RS12515 (2590830) 2590830..2591810 - 981 WP_017441090.1 tRNA-modifying protein YgfZ -
PQP75_RS12520 (2592060) 2592060..2592326 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQP75_RS12525 (2592307) 2592307..2592720 + 414 WP_000244755.1 protein YgfX Toxin
PQP75_RS12530 (2592773) 2592773..2593294 - 522 WP_017441091.1 flavodoxin FldB -
PQP75_RS12535 (2593407) 2593407..2594303 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PQP75_RS12540 (2594327) 2594327..2595040 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQP75_RS12545 (2595046) 2595046..2596779 + 1734 WP_000813392.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16164.10 Da        Isoelectric Point: 10.2118

>T270029 WP_000244755.1 NZ_CP117181:2592307-2592720 [Salmonella enterica subsp. enterica serovar Mbandaka]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLHPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270029 WP_000351186.1 NZ_CP117181:2592060-2592326 [Salmonella enterica subsp. enterica serovar Mbandaka]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SJP5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References