Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2068845..2069636 Replicon chromosome
Accession NZ_CP117181
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28S

Toxin (Protein)


Gene name ataT Uniprot ID C0Q119
Locus tag PQP75_RS09920 Protein ID WP_000369560.1
Coordinates 2069118..2069636 (+) Length 173 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q57IR1
Locus tag PQP75_RS09915 Protein ID WP_001275017.1
Coordinates 2068845..2069114 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP75_RS09895 (2064426) 2064426..2065094 + 669 WP_000617729.1 cell division ATP-binding protein FtsE -
PQP75_RS09900 (2065087) 2065087..2066142 + 1056 WP_001081707.1 permease-like cell division protein FtsX -
PQP75_RS09905 (2066388) 2066388..2067242 + 855 WP_000159621.1 RNA polymerase sigma factor RpoH -
PQP75_RS09910 (2067564) 2067564..2068667 + 1104 WP_001528146.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PQP75_RS09915 (2068845) 2068845..2069114 + 270 WP_001275017.1 DUF1778 domain-containing protein Antitoxin
PQP75_RS09920 (2069118) 2069118..2069636 + 519 WP_000369560.1 GNAT family N-acetyltransferase Toxin
PQP75_RS09925 (2069633) 2069633..2070016 - 384 WP_000778873.1 aspartate 1-decarboxylase autocleavage activator PanM -
PQP75_RS09930 (2070438) 2070438..2071547 + 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PQP75_RS09935 (2071607) 2071607..2072533 + 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PQP75_RS09940 (2072530) 2072530..2073807 + 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
PQP75_RS09945 (2073804) 2073804..2074571 + 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19414.16 Da        Isoelectric Point: 8.9619

>T270026 WP_000369560.1 NZ_CP117181:2069118-2069636 [Salmonella enterica subsp. enterica serovar Mbandaka]
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG

Download         Length: 519 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10086.53 Da        Isoelectric Point: 7.2056

>AT270026 WP_001275017.1 NZ_CP117181:2068845-2069114 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5BA59

Antitoxin

Source ID Structure
AlphaFold DB A0A5I8URP5

References