Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1241362..1242143 Replicon chromosome
Accession NZ_CP117181
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28S

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag PQP75_RS06045 Protein ID WP_000625911.1
Coordinates 1241362..1241853 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag PQP75_RS06050 Protein ID WP_001271379.1
Coordinates 1241850..1242143 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP75_RS06020 (1236496) 1236496..1238934 - 2439 WP_017441226.1 F4 (K88) fimbrial usher FaeD -
PQP75_RS06025 (1238944) 1238944..1239483 - 540 WP_000721295.1 type 1 fimbrial protein -
PQP75_RS06030 (1239518) 1239518..1239808 - 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
PQP75_RS06035 (1240396) 1240396..1240653 + 258 WP_001112996.1 hypothetical protein -
PQP75_RS06040 (1240899) 1240899..1241147 - 249 Protein_1176 IS481 family transposase -
PQP75_RS06045 (1241362) 1241362..1241853 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
PQP75_RS06050 (1241850) 1241850..1242143 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
PQP75_RS06055 (1242461) 1242461..1242682 + 222 WP_001595143.1 hypothetical protein -
PQP75_RS06060 (1242948) 1242948..1243823 + 876 WP_017441228.1 AraC family transcriptional regulator -
PQP75_RS06065 (1243820) 1243820..1244107 + 288 WP_072103482.1 transcriptional regulator RtsB -
PQP75_RS06070 (1244114) 1244114..1244281 - 168 WP_071527476.1 ATP-binding cassette domain-containing protein -
PQP75_RS06075 (1244301) 1244301..1244400 + 100 Protein_1183 hypothetical protein -
PQP75_RS06080 (1244448) 1244448..1244642 + 195 WP_223195369.1 hypothetical protein -
PQP75_RS06085 (1244936) 1244936..1245841 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 1229752..1244107 14355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T270023 WP_000625911.1 NZ_CP117181:c1241853-1241362 [Salmonella enterica subsp. enterica serovar Mbandaka]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT270023 WP_001271379.1 NZ_CP117181:c1242143-1241850 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References