Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1096683..1097326 Replicon chromosome
Accession NZ_CP117181
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28S

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag PQP75_RS05305 Protein ID WP_017441191.1
Coordinates 1096910..1097326 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag PQP75_RS05300 Protein ID WP_001261294.1
Coordinates 1096683..1096913 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP75_RS05290 (1093697) 1093697..1095835 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
PQP75_RS05295 (1096052) 1096052..1096516 + 465 WP_017441190.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQP75_RS05300 (1096683) 1096683..1096913 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PQP75_RS05305 (1096910) 1096910..1097326 + 417 WP_017441191.1 type II toxin-antitoxin system VapC family toxin Toxin
PQP75_RS05310 (1097387) 1097387..1099300 - 1914 WP_023242878.1 BglG family transcription antiterminator -
PQP75_RS05315 (1099317) 1099317..1100057 - 741 WP_023229489.1 KDGP aldolase family protein -
PQP75_RS05320 (1100054) 1100054..1101172 - 1119 WP_001139194.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQP75_RS05325 (1101156) 1101156..1102289 - 1134 WP_017441192.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15163.55 Da        Isoelectric Point: 8.1381

>T270022 WP_017441191.1 NZ_CP117181:1096910-1097326 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAVGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT270022 WP_001261294.1 NZ_CP117181:1096683-1096913 [Salmonella enterica subsp. enterica serovar Mbandaka]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References