Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 887601..889224 | Replicon | chromosome |
| Accession | NZ_CP117181 | ||
| Organism | Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28S | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | H9TH67 |
| Locus tag | PQP75_RS04305 | Protein ID | WP_000088046.1 |
| Coordinates | 887899..889224 (+) | Length | 442 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A5Z6V2D1 |
| Locus tag | PQP75_RS04300 | Protein ID | WP_024136327.1 |
| Coordinates | 887601..887894 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PQP75_RS04265 (882623) | 882623..883750 | - | 1128 | WP_014837927.1 | DUF3883 domain-containing protein | - |
| PQP75_RS04270 (883801) | 883801..884028 | - | 228 | WP_000248278.1 | hypothetical protein | - |
| PQP75_RS04275 (884052) | 884052..884243 | + | 192 | WP_000951934.1 | hypothetical protein | - |
| PQP75_RS04280 (884725) | 884725..885267 | - | 543 | WP_000587837.1 | AAA family ATPase | - |
| PQP75_RS04285 (885280) | 885280..886140 | - | 861 | WP_000557454.1 | aminoglycoside N-acetyltransferase AAC(3)-IId | - |
| PQP75_RS04290 (886283) | 886283..886405 | + | 123 | Protein_834 | IS4 family transposase | - |
| PQP75_RS04295 (886457) | 886457..887161 | - | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| PQP75_RS04300 (887601) | 887601..887894 | + | 294 | WP_024136327.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| PQP75_RS04305 (887899) | 887899..889224 | + | 1326 | WP_000088046.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| PQP75_RS04310 (889285) | 889285..889491 | + | 207 | WP_000134171.1 | hypothetical protein | - |
| PQP75_RS04315 (889593) | 889593..890003 | + | 411 | WP_000985911.1 | hypothetical protein | - |
| PQP75_RS04320 (890016) | 890016..890831 | + | 816 | WP_001572439.1 | HNH endonuclease signature motif containing protein | - |
| PQP75_RS04325 (891085) | 891085..891510 | + | 426 | WP_001043843.1 | hypothetical protein | - |
| PQP75_RS04330 (892059) | 892059..892367 | + | 309 | WP_001224687.1 | hypothetical protein | - |
| PQP75_RS04335 (892383) | 892383..893240 | + | 858 | WP_000784387.1 | HNH endonuclease signature motif containing protein | - |
| PQP75_RS04340 (893302) | 893302..893505 | + | 204 | WP_001194555.1 | hypothetical protein | - |
| PQP75_RS04345 (893847) | 893847..894203 | - | 357 | WP_065311124.1 | H-NS family nucleoid-associated regulatory protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50249.20 Da Isoelectric Point: 6.1927
>T270020 WP_000088046.1 NZ_CP117181:887899-889224 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10946.35 Da Isoelectric Point: 10.0925
>AT270020 WP_024136327.1 NZ_CP117181:887601-887894 [Salmonella enterica subsp. enterica serovar Mbandaka]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3T0VBU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Z6V2D1 |