Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 310576..311196 Replicon chromosome
Accession NZ_CP117181
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28S

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP75_RS01515 Protein ID WP_001280991.1
Coordinates 310978..311196 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP75_RS01510 Protein ID WP_000344807.1
Coordinates 310576..310950 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP75_RS01500 (305715) 305715..306908 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP75_RS01505 (306931) 306931..310080 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQP75_RS01510 (310576) 310576..310950 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP75_RS01515 (310978) 310978..311196 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP75_RS01520 (311375) 311375..311926 + 552 WP_001278793.1 maltose O-acetyltransferase -
PQP75_RS01525 (312042) 312042..312512 + 471 WP_000136183.1 YlaC family protein -
PQP75_RS01530 (312568) 312568..312708 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP75_RS01535 (312714) 312714..312974 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP75_RS01540 (313199) 313199..314749 + 1551 WP_000213140.1 EAL domain-containing protein -
PQP75_RS01550 (314980) 314980..315369 + 390 WP_000961285.1 MGMT family protein -
PQP75_RS01555 (315402) 315402..315971 - 570 WP_000779801.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270013 WP_001280991.1 NZ_CP117181:310978-311196 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270013 WP_000344807.1 NZ_CP117181:310576-310950 [Salmonella enterica subsp. enterica serovar Mbandaka]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References