Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2125855..2126492 Replicon chromosome
Accession NZ_CP117168
Organism Serratia proteamaculans strain CD3406

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JET59_RS10045 Protein ID WP_219015875.1
Coordinates 2126217..2126492 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JET59_RS10040 Protein ID WP_219015874.1
Coordinates 2125855..2126220 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JET59_RS10025 (JET59_010025) 2121198..2122031 - 834 WP_219015871.1 GPO family capsid scaffolding protein -
JET59_RS10030 (JET59_010030) 2122190..2123911 + 1722 WP_219015872.1 terminase family protein -
JET59_RS10035 (JET59_010035) 2123913..2124968 + 1056 WP_219015873.1 phage portal protein -
JET59_RS10040 (JET59_010040) 2125855..2126220 - 366 WP_219015874.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JET59_RS10045 (JET59_010045) 2126217..2126492 - 276 WP_219015875.1 type II toxin-antitoxin system HicA family toxin Toxin
JET59_RS10050 (JET59_010050) 2126567..2126938 - 372 WP_219015876.1 ClpX C4-type zinc finger protein -
JET59_RS10055 (JET59_010055) 2126953..2127645 - 693 WP_219015877.1 DNA adenine methylase -
JET59_RS10060 (JET59_010060) 2127824..2130283 - 2460 WP_219015878.1 replication endonuclease -
JET59_RS10065 (JET59_010065) 2130280..2130822 - 543 WP_219015879.1 ead/Ea22-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2102648..2138025 35377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(62-114)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10126.72 Da        Isoelectric Point: 10.6115

>T270001 WP_219015875.1 NZ_CP117168:c2126492-2126217 [Serratia proteamaculans]
MKEQVSALRKRQKSTLEQIFKTPVLSGIKWSDVESLIKALGGEVKEGRGSRCKFLLNGSIANFHRPHPSPDTDKGAVVNL
REWLESIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13315.04 Da        Isoelectric Point: 4.7301

>AT270001 WP_219015874.1 NZ_CP117168:c2126220-2125855 [Serratia proteamaculans]
MTKTVAAAPNTMEIAGQPAIISYVPEIGAFRGKFLGLTGYCDFVSDSIQGLHAEGEISLREYLDDCSAAGIEPYARQEKI
KTFTLRYPESFGERLNQAAAEHEVSVNAFIVETLNERMKHA

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References