Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1796162..1796715 Replicon chromosome
Accession NZ_CP117168
Organism Serratia proteamaculans strain CD3406

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag JET59_RS08530 Protein ID WP_207975747.1
Coordinates 1796401..1796715 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A379YKU0
Locus tag JET59_RS08525 Protein ID WP_012005987.1
Coordinates 1796162..1796398 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JET59_RS08510 (JET59_008510) 1792136..1793674 + 1539 WP_099064102.1 glutathione ABC transporter substrate-binding protein GsiB -
JET59_RS08515 (JET59_008515) 1793725..1794645 + 921 WP_099064103.1 glutathione ABC transporter permease GsiC -
JET59_RS08520 (JET59_008520) 1794655..1795563 + 909 WP_099064104.1 glutathione ABC transporter permease GsiD -
JET59_RS08525 (JET59_008525) 1796162..1796398 + 237 WP_012005987.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
JET59_RS08530 (JET59_008530) 1796401..1796715 + 315 WP_207975747.1 CcdB family protein Toxin
JET59_RS08535 (JET59_008535) 1796753..1797595 - 843 WP_219015745.1 S-formylglutathione hydrolase -
JET59_RS08540 (JET59_008540) 1797610..1798737 - 1128 WP_198404463.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
JET59_RS08545 (JET59_008545) 1798765..1799682 - 918 WP_099064108.1 LysR family transcriptional regulator -
JET59_RS08550 (JET59_008550) 1799789..1800946 + 1158 WP_219015746.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11669.53 Da        Isoelectric Point: 4.7526

>T269999 WP_207975747.1 NZ_CP117168:1796401-1796715 [Serratia proteamaculans]
MQFTVYANTGKSTVYPLLLDVTSDIIGQLNRRVVIPLLPIEKYPGSTRPERLIPLVRLVDDNEYAVMTHEMASIPVRTLG
AEFCDATQYRTEVKAAIDFLLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9108.19 Da        Isoelectric Point: 6.7184

>AT269999 WP_012005987.1 NZ_CP117168:1796162-1796398 [Serratia proteamaculans]
MPVKQRTTQSVTMTVERSLLSRAREAGINLSATLNAALDAELRQHEMRKWKEDNREAIEALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A379YKU0

References