Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4018046..4019617 Replicon chromosome
Accession NZ_CP117166
Organism Proteus mirabilis strain 181-3b

Toxin (Protein)


Gene name hipA Uniprot ID M9PP16
Locus tag PRR80_RS18535 Protein ID WP_004249772.1
Coordinates 4018046..4019359 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B4F0T9
Locus tag PRR80_RS18540 Protein ID WP_004249771.1
Coordinates 4019360..4019617 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRR80_RS18515 (PRR80_18515) 4013215..4014018 + 804 WP_164527720.1 energy transducer TonB -
PRR80_RS18520 (PRR80_18520) 4014072..4016033 - 1962 WP_004249953.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
PRR80_RS18525 (PRR80_18525) 4016065..4016994 - 930 WP_004246518.1 metallophosphoesterase -
PRR80_RS18530 (PRR80_18530) 4017179..4017643 - 465 WP_004249773.1 DUF1097 domain-containing protein -
PRR80_RS18535 (PRR80_18535) 4018046..4019359 - 1314 WP_004249772.1 type II toxin-antitoxin system HipA family toxin Toxin
PRR80_RS18540 (PRR80_18540) 4019360..4019617 - 258 WP_004249771.1 helix-turn-helix domain-containing protein Antitoxin
PRR80_RS18545 (PRR80_18545) 4019766..4021130 - 1365 WP_004246513.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
PRR80_RS18550 (PRR80_18550) 4021268..4022908 - 1641 WP_004246512.1 membrane protein insertase YidC -
PRR80_RS18555 (PRR80_18555) 4022911..4023171 - 261 WP_012368639.1 membrane protein insertion efficiency factor YidD -
PRR80_RS18560 (PRR80_18560) 4023135..4023494 - 360 WP_004246510.1 ribonuclease P protein component -
PRR80_RS18565 (PRR80_18565) 4023512..4023655 - 144 WP_004246509.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49658.73 Da        Isoelectric Point: 6.5023

>T269992 WP_004249772.1 NZ_CP117166:c4019359-4018046 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDTELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Download         Length: 1314 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT269992 WP_004249771.1 NZ_CP117166:c4019617-4019360 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M9PP16

Antitoxin

Source ID Structure
AlphaFold DB B4F0T9

References