Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3712926..3713625 Replicon chromosome
Accession NZ_CP117166
Organism Proteus mirabilis strain 181-3b

Toxin (Protein)


Gene name relE Uniprot ID B4EZ96
Locus tag PRR80_RS17175 Protein ID WP_004249093.1
Coordinates 3712926..3713312 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag PRR80_RS17180 Protein ID WP_004246828.1
Coordinates 3713305..3713625 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRR80_RS17160 (PRR80_17160) 3708939..3709520 - 582 WP_012368524.1 DNA-3-methyladenine glycosylase I -
PRR80_RS17165 (PRR80_17165) 3709771..3710676 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
PRR80_RS17170 (PRR80_17170) 3710686..3712758 + 2073 WP_017827114.1 glycine--tRNA ligase subunit beta -
PRR80_RS17175 (PRR80_17175) 3712926..3713312 + 387 WP_004249093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PRR80_RS17180 (PRR80_17180) 3713305..3713625 + 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
PRR80_RS17185 (PRR80_17185) 3713676..3714110 - 435 WP_004246827.1 hypothetical protein -
PRR80_RS17190 (PRR80_17190) 3714103..3714987 - 885 WP_004249091.1 endonuclease/exonuclease/phosphatase family protein -
PRR80_RS17195 (PRR80_17195) 3715205..3716491 - 1287 WP_074561560.1 DUF3748 domain-containing protein -
PRR80_RS17200 (PRR80_17200) 3716628..3717245 + 618 WP_004246822.1 trimeric intracellular cation channel family protein -
PRR80_RS17205 (PRR80_17205) 3717547..3718170 + 624 WP_004246821.1 guanylate kinase -
PRR80_RS17210 (PRR80_17210) 3718225..3718500 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14294.64 Da        Isoelectric Point: 10.0642

>T269991 WP_004249093.1 NZ_CP117166:3712926-3713312 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT269991 WP_004246828.1 NZ_CP117166:3713305-3713625 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZ96

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References