Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 3349489..3351211 | Replicon | chromosome |
| Accession | NZ_CP117166 | ||
| Organism | Proteus mirabilis strain 181-3b | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A0U2S2I2 |
| Locus tag | PRR80_RS15565 | Protein ID | WP_064497040.1 |
| Coordinates | 3349489..3350427 (-) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A0A934MVJ4 |
| Locus tag | PRR80_RS15570 | Protein ID | WP_000095577.1 |
| Coordinates | 3350420..3351211 (-) | Length | 264 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PRR80_RS15545 (PRR80_15545) | 3345430..3345942 | - | 513 | WP_175215521.1 | S26 family signal peptidase | - |
| PRR80_RS15550 (PRR80_15550) | 3345926..3346273 | - | 348 | WP_064497038.1 | hypothetical protein | - |
| PRR80_RS15555 (PRR80_15555) | 3346266..3348665 | - | 2400 | WP_064497039.1 | type IV secretion system protein TraC | - |
| PRR80_RS15560 (PRR80_15560) | 3348665..3349357 | - | 693 | WP_001228924.1 | DsbC family protein | - |
| PRR80_RS15565 (PRR80_15565) | 3349489..3350427 | - | 939 | WP_064497040.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| PRR80_RS15570 (PRR80_15570) | 3350420..3351211 | - | 792 | WP_000095577.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| PRR80_RS15575 (PRR80_15575) | 3351432..3351818 | - | 387 | WP_032469918.1 | TraA family conjugative transfer protein | - |
| PRR80_RS15580 (PRR80_15580) | 3351815..3352387 | - | 573 | WP_024008834.1 | type IV conjugative transfer system lipoprotein TraV | - |
| PRR80_RS15585 (PRR80_15585) | 3352462..3353751 | - | 1290 | WP_064497041.1 | TraB/VirB10 family protein | - |
| PRR80_RS15590 (PRR80_15590) | 3353754..3354650 | - | 897 | WP_064497055.1 | type-F conjugative transfer system secretin TraK | - |
| PRR80_RS15595 (PRR80_15595) | 3354634..3355260 | - | 627 | WP_064497042.1 | TraE/TraK family type IV conjugative transfer system protein | - |
| PRR80_RS15600 (PRR80_15600) | 3355257..3355538 | - | 282 | WP_000433891.1 | type IV conjugative transfer system protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | tet(J) / aadA2 / ere(A) / aac(3)-IVa / aph(4)-Ia / sul2 / floR / blaCTX-M-65 / fosA3 / aph(3')-Ia / tet(C) / aph(3'')-Ib / aph(6)-Id | - | 3218628..3399537 | 180909 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 35542.81 Da Isoelectric Point: 4.9912
>T269990 WP_064497040.1 NZ_CP117166:c3350427-3349489 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIIVSSPVATIKIEVSPVARGTLHSAEIMAVQESVEYEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLTSLQK
HFTERDYAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIIVSSPVATIKIEVSPVARGTLHSAEIMAVQESVEYEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLTSLQK
HFTERDYAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
Download Length: 939 bp
Antitoxin
Download Length: 264 a.a. Molecular weight: 30109.49 Da Isoelectric Point: 9.5097
>AT269990 WP_000095577.1 NZ_CP117166:c3351211-3350420 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
Download Length: 792 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|