Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1692043..1692842 Replicon chromosome
Accession NZ_CP117166
Organism Proteus mirabilis strain 181-3b

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A8E3RD10
Locus tag PRR80_RS07925 Protein ID WP_004247966.1
Coordinates 1692318..1692842 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID B4EVS2
Locus tag PRR80_RS07920 Protein ID WP_004247964.1
Coordinates 1692043..1692321 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRR80_RS07895 (PRR80_07895) 1687393..1688475 + 1083 WP_004242680.1 peptide chain release factor 1 -
PRR80_RS07900 (PRR80_07900) 1688475..1689323 + 849 WP_164527482.1 peptide chain release factor N(5)-glutamine methyltransferase -
PRR80_RS07905 (PRR80_07905) 1689301..1690116 + 816 WP_088207195.1 invasion regulator SirB1 -
PRR80_RS07910 (PRR80_07910) 1690174..1691028 + 855 WP_004242689.1 3-deoxy-8-phosphooctulonate synthase -
PRR80_RS07915 (PRR80_07915) 1691036..1691965 + 930 WP_004242691.1 TIGR01212 family radical SAM protein -
PRR80_RS07920 (PRR80_07920) 1692043..1692321 + 279 WP_004247964.1 DUF1778 domain-containing protein Antitoxin
PRR80_RS07925 (PRR80_07925) 1692318..1692842 + 525 WP_004247966.1 hypothetical protein Toxin
PRR80_RS07930 (PRR80_07930) 1692923..1694623 - 1701 WP_004242694.1 C4-dicarboxylic acid transporter DauA -
PRR80_RS07940 (PRR80_07940) 1695586..1696527 + 942 WP_004242695.1 glyoxylate/hydroxypyruvate reductase GhrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(5-87)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19192.12 Da        Isoelectric Point: 9.3561

>T269988 WP_004247966.1 NZ_CP117166:1692318-1692842 [Proteus mirabilis]
MTIPNWHEEAISKKHNRNGFNCGDAVLNQFLYRHARQNHENGSAKTYLAINNSNNIILGYYSLCPASIEFERTPELIKHG
LARHDIPVFKLARLATDLSVQGKGLGGQLLLAAGRRCLSVASELGGVALLIDAKNERVANWYISYGAIPLLDTPLSLLIS
FKTIYTALSMANKI

Download         Length: 525 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10252.82 Da        Isoelectric Point: 5.1369

>AT269988 WP_004247964.1 NZ_CP117166:1692043-1692321 [Proteus mirabilis]
MAQALVENSERVSIRITTEDKSLLVRAASLENTNLTEFVLRNIVPVARQVIENNERLKLSEKDTLRVMELLDNPPKPNAK
LLAAAFALPDNA

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4EVS2

References