Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3571019..3571637 Replicon chromosome
Accession NZ_CP117053
Organism Escherichia coli strain MLI106K4

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NL407_RS18555 Protein ID WP_001291435.1
Coordinates 3571419..3571637 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NL407_RS18550 Protein ID WP_000344800.1
Coordinates 3571019..3571393 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL407_RS18540 (3566108) 3566108..3567301 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL407_RS18545 (3567324) 3567324..3570473 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NL407_RS18550 (3571019) 3571019..3571393 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NL407_RS18555 (3571419) 3571419..3571637 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NL407_RS18560 (3571809) 3571809..3572360 + 552 WP_000102564.1 maltose O-acetyltransferase -
NL407_RS18565 (3572476) 3572476..3572946 + 471 WP_000136192.1 YlaC family protein -
NL407_RS18570 (3573110) 3573110..3574660 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NL407_RS18575 (3574702) 3574702..3575055 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NL407_RS18585 (3575434) 3575434..3575745 + 312 WP_000409911.1 MGMT family protein -
NL407_RS18590 (3575776) 3575776..3576348 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269966 WP_001291435.1 NZ_CP117053:3571419-3571637 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269966 WP_000344800.1 NZ_CP117053:3571019-3571393 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References