Detailed information of TA system TA026994

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 1972699..1973434
• Replicon: chromosome
• Accession: NC_017554
• Organism: Pantoea ananatis PA13

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A8A4K8B1
• Locus tag: PAGR_RS09200
• Protein ID: WP_014605594.1
• Coordinates: 1972699..1973091 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: PAGR_RS09205
• Protein ID: WP_014605595.1
• Coordinates: 1973081..1973434 (+)
• Length: 118 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PAGR_RS09185	1967995..1969167	-	1173	WP_013026120.1	FMNH2-dependent alkanesulfonate monooxygenase	-
PAGR_RS09190	1969446..1971332	+	1887	WP_044042534.1	aliphatic sulfonate ABC transporter substrate-binding protein	-
PAGR_RS09195	1971427..1972374	+	948	WP_014605593.1	sulfonate ABC transporter substrate-binding protein	-
PAGR_RS09200	1972699..1973091	+	393	WP_014605594.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PAGR_RS09205	1973081..1973434	+	354	WP_014605595.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
PAGR_RS09210	1974145..1975323	-	1179	WP_014605596.1	tyrosine-type recombinase/integrase	-
PAGR_RS09220	1975484..1977562	-	2079	WP_014605598.1	DNA cytosine methyltransferase	-
PAGR_RS09225	1977559..1978431	-	873	WP_014605599.1	phage N-6-adenine-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1961343..1975323	13980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (6-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (56-99)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14987.27 Da
• Isoelectric Point: 10.1741

>T26994 WP_014605594.1 NC_017554:1972699-1973091 [Pantoea ananatis PA13]
MGFTLYVHKRFDRVFKKTRLTDSVLCYAAGDVFTGVFEADLGGGVIKKRLALHQGKRGGARTVIFFRQGTNLVYYDGWVK
NLSRKYAREIDEDQLDTYRDVARMFFRANSEVMSLLVRSGMVREVKCNEN

Nucleotide

• Length: 393 bp

>T26994 NC_017554:1972699-1973091 [Pantoea ananatis PA13]
ATGGGTTTTACGCTTTATGTTCATAAACGTTTTGACAGAGTGTTTAAAAAAACGCGTCTGACAGACAGCGTCCTGTGTTA
CGCAGCAGGTGACGTTTTTACTGGCGTGTTTGAGGCTGACTTAGGCGGTGGCGTTATTAAAAAGCGTCTTGCTCTTCACC
AAGGCAAGCGTGGCGGCGCGCGAACGGTCATCTTCTTCAGACAAGGCACCAACCTGGTTTATTACGATGGATGGGTCAAA
AACTTGTCGAGGAAATACGCCAGGGAAATCGATGAAGATCAGCTGGATACCTACAGGGATGTGGCAAGAATGTTTTTCCG
TGCAAATAGTGAAGTGATGAGCCTGCTCGTCAGAAGCGGAATGGTCAGAGAGGTTAAATGTAATGAAAACTGA

Antitoxin

Protein

• Length: 118 a.a.
• Molecular weight: 13096.14 Da
• Isoelectric Point: 7.2076

>AT26994 WP_014605595.1 NC_017554:1973081-1973434 [Pantoea ananatis PA13]
MKTEPAELSELLEDAKAFHALGLATDEEVESIAKRAKNRELRARIASVKPMTATEIKDVRMRWGMSQSLVALSFGMTVDS
VSKWERGEITPSPPVMRMLQLLRDNGPELFTSKHQGI

Nucleotide

• Length: 354 bp

>AT26994 NC_017554:1973081-1973434 [Pantoea ananatis PA13]
ATGAAAACTGAACCCGCCGAATTGAGTGAACTACTTGAAGATGCGAAAGCGTTTCACGCGTTAGGACTGGCAACAGATGA
AGAAGTGGAGTCCATAGCAAAGCGCGCAAAAAATCGTGAACTCCGTGCCCGTATTGCATCAGTAAAGCCCATGACAGCAA
CTGAAATCAAAGACGTGCGCATGCGTTGGGGAATGTCGCAATCGCTTGTGGCTCTCTCATTTGGCATGACGGTCGATAGC
GTATCGAAATGGGAGCGAGGTGAAATCACACCGAGCCCACCGGTGATGCGGATGCTGCAACTCCTTCGCGATAACGGCCC
TGAACTCTTTACCTCTAAGCATCAAGGTATCTAG