Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2541303..2541941 Replicon chromosome
Accession NZ_CP117049
Organism Escherichia coli strain MLI106K2

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag NL423_RS13465 Protein ID WP_001447010.1
Coordinates 2541765..2541941 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NL423_RS13460 Protein ID WP_001270286.1
Coordinates 2541303..2541719 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL423_RS13440 (2536455) 2536455..2537396 - 942 WP_001251304.1 ABC transporter permease -
NL423_RS13445 (2537397) 2537397..2538410 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
NL423_RS13450 (2538428) 2538428..2539573 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
NL423_RS13455 (2539818) 2539818..2541224 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
NL423_RS13460 (2541303) 2541303..2541719 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NL423_RS13465 (2541765) 2541765..2541941 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NL423_RS13470 (2542163) 2542163..2542393 + 231 WP_000494244.1 YncJ family protein -
NL423_RS13475 (2542485) 2542485..2544446 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NL423_RS13480 (2544519) 2544519..2545055 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
NL423_RS13485 (2545147) 2545147..2546322 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T269932 WP_001447010.1 NZ_CP117049:c2541941-2541765 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT269932 WP_001270286.1 NZ_CP117049:c2541719-2541303 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References