Detailed information of TA system TA026992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 137764..138671
• Replicon: plasmid PAGR_p
• Accession: NC_017553
• Organism: Pantoea ananatis PA13

Toxin (Protein)

• Gene name: -
• Uniprot ID: D4GET9
• Locus tag: PAGR_RS22105
• Protein ID: WP_013027861.1
• Coordinates: 137764..138231 (-)
• Length: 156 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A8A4JZ23
• Locus tag: PAGR_RS22110
• Protein ID: WP_014598335.1
• Coordinates: 138228..138671 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PAGR_RS23430	133150..133383	-	234	WP_013027857.1	DUF333 domain-containing protein	-
PAGR_RS22090	133471..134043	+	573	WP_044042698.1	NAD(P)H-dependent oxidoreductase	-
PAGR_RS22095	134105..135040	-	936	WP_013027859.1	hypothetical protein	-
PAGR_RS22100	135725..137119	-	1395	WP_014604629.1	flagellar filament capping protein FliD	-
PAGR_RS22105	137764..138231	-	468	WP_013027861.1	RES family NAD+ phosphorylase	Toxin
PAGR_RS22110	138228..138671	-	444	WP_014598335.1	DUF2384 domain-containing protein	Antitoxin
PAGR_RS23435	139057..139281	+	225	WP_013027863.1	KTSC domain-containing protein	-
PAGR_RS22115	139435..140130	+	696	WP_014598334.1	hypothetical protein	-
PAGR_RS22120	140205..140894	-	690	WP_014598333.1	HTH-type transcriptional regulator RutR	-
PAGR_RS22125	141293..142384	+	1092	WP_014604632.1	pyrimidine utilization protein A	-
PAGR_RS22130	142381..143133	+	753	WP_014604633.1	pyrimidine utilization protein B	-
PAGR_RS22135	143159..143545	+	387	WP_013027868.1	pyrimidine utilization protein C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	fliC / fliC	1..280753	280753

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-145)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (31-89)

Sequences

Toxin

Protein

• Length: 156 a.a.
• Molecular weight: 17207.70 Da
• Isoelectric Point: 5.1570

>T26992 WP_013027861.1 NC_017553:c138231-137764 [Pantoea ananatis PA13]
MKLYRMTKTRYLGSAWSGFGAREGGGRWNSVGVSMVYASETASLTMLETLIHLQSASVLDFFTLMSIDVPDRLIEWIDIK
QLPDDWAAPEAPAALRLFGDAWIQSGGSVALRVPSALSPVESNYLLNPEHPEFSAIVRQAVNIPFLFDARFSRQV

Nucleotide

• Length: 468 bp

>T26992 NC_017553:c138231-137764 [Pantoea ananatis PA13]
TTGAAGCTCTATCGCATGACCAAAACGCGCTATCTGGGGTCGGCCTGGAGCGGTTTTGGTGCCCGTGAAGGCGGCGGACG
CTGGAACAGCGTCGGCGTATCGATGGTCTACGCTTCTGAAACTGCTTCCCTCACCATGCTGGAGACGCTTATCCATCTGC
AAAGCGCCAGCGTGCTGGACTTTTTTACCCTCATGAGCATTGACGTTCCCGACAGGCTGATTGAATGGATTGATATCAAG
CAACTGCCTGACGACTGGGCCGCACCGGAAGCGCCTGCAGCGCTGCGTTTATTTGGTGATGCCTGGATACAAAGCGGGGG
ATCGGTCGCACTGCGCGTGCCCAGTGCCCTTTCGCCCGTGGAATCGAATTATCTTCTCAATCCCGAGCATCCTGAATTCA
GTGCGATCGTCAGACAGGCGGTAAACATCCCCTTCCTTTTTGACGCACGTTTTTCCCGACAGGTATAA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16375.69 Da
• Isoelectric Point: 7.0208

>AT26992 WP_014598335.1 NC_017553:c138671-138228 [Pantoea ananatis PA13]
MKQFTLPVSAAEPDRLWQFAGLSSADGVMLMDQIDDGLDGTVASRIVTWAQISQAELRRMTGIAGSTFTRGVKSRFTAEQ
SERLVRFIRVMDRAVELFEGDKEKARQWLNEPARALGNKKPADLVASETGAYEVLKLITRLEHGVYS

Nucleotide

• Length: 444 bp

>AT26992 NC_017553:c138671-138228 [Pantoea ananatis PA13]
ATGAAACAGTTCACTTTACCCGTATCCGCTGCAGAACCGGATCGTCTATGGCAATTTGCTGGCCTGAGCAGTGCTGACGG
CGTGATGCTGATGGATCAAATCGATGATGGTCTGGACGGCACGGTAGCCAGTCGCATTGTCACCTGGGCGCAAATCTCTC
AGGCAGAACTGCGCCGTATGACCGGCATTGCGGGCTCAACCTTCACCCGCGGCGTTAAAAGCCGCTTTACTGCGGAGCAG
AGCGAACGGCTGGTGCGTTTTATTCGCGTGATGGATCGTGCGGTTGAGCTGTTTGAGGGTGATAAAGAAAAGGCACGGCA
GTGGCTCAATGAGCCTGCGCGCGCCTTAGGCAATAAAAAACCGGCCGATCTGGTTGCGTCAGAAACCGGTGCTTATGAAG
TGCTGAAACTCATTACCCGGCTTGAACACGGTGTGTATTCTTGA