26991

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 2821811..2822387 Replicon chromosome
Accession NC_017551
Organism Leptospira interrogans serovar Lai str. IPAV

Toxin (Protein)


Gene name chpK Uniprot ID Q93MT8
Locus tag LIF_RS12170 Protein ID WP_000617906.1
Coordinates 2821811..2822152 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID Q93MT9
Locus tag LIF_RS12175 Protein ID WP_000844758.1
Coordinates 2822139..2822387 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIF_RS12145 2817332..2817736 - 405 WP_001974506.1 pyridoxamine 5'-phosphate oxidase family protein -
LIF_RS12150 2817733..2818200 - 468 WP_000060051.1 hypothetical protein -
LIF_RS12160 2819004..2819939 + 936 WP_000004530.1 ornithine carbamoyltransferase -
LIF_RS12165 2820079..2821071 + 993 WP_000041092.1 aldolase -
LIF_RS12170 2821811..2822152 - 342 WP_000617906.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LIF_RS12175 2822139..2822387 - 249 WP_000844758.1 ribbon-helix-helix domain-containing protein Antitoxin
LIF_RS12180 2823204..2823500 - 297 WP_000477061.1 helix-turn-helix domain-containing protein -
LIF_RS23450 2823654..2824113 + 460 Protein_2325 hypothetical protein -
LIF_RS12190 2824755..2826737 - 1983 WP_000836895.1 HD family phosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12372.25 Da        Isoelectric Point: 6.3272

>T26991 WP_000617906.1 NC_017551:c2822152-2821811 [Leptospira interrogans serovar Lai str. IPAV]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVFISKKDSSLSKDSVINVSQIV
TLDKERFLNKAGKLKSNKLGEVEIGLKLVTGLD

Download         Length: 342 bp

>T26991 NC_017551:c2822152-2821811 [Leptospira interrogans serovar Lai str. IPAV]
ATGATTCGTGGTGAAATTTGGTGGGTAGACTTGGGAATTCCATTTGGAAGTGAGCCTGGATTTAAACGTCCAGTTCTTAT
AATTCAAGATGACTCTTTTAATCAAAGTAATATTAATACAATAGTTTCGATTGCAATTACATCGAATTTAAATCTATCTG
AAGCACCAGGTAATGTTTTCATTAGTAAAAAAGATTCGAGTTTATCAAAGGACTCGGTCATAAATGTTTCTCAAATTGTG
ACTTTAGATAAAGAAAGATTTCTTAACAAAGCGGGTAAACTTAAATCAAATAAATTAGGTGAAGTTGAAATTGGGCTTAA
GTTGGTTACAGGCTTAGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9380.77 Da        Isoelectric Point: 10.3815

>AT26991 WP_000844758.1 NC_017551:c2822387-2822139 [Leptospira interrogans serovar Lai str. IPAV]
MKTAISIPDELFRAAEKIAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKIYSNKSKETRNNITDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT26991 NC_017551:c2822387-2822139 [Leptospira interrogans serovar Lai str. IPAV]
ATGAAGACGGCGATTTCAATTCCTGATGAGTTATTTAGGGCTGCCGAGAAAATAGCTAAAAAACTTGGGATTCCTCGAAG
CCAGTTATTTGCAAAAGCATTAGAAGAATTTATCCAATCTCATAGTAAAGAATCTGTAACTGAGAAATTAAATAAAATCT
ACAGTAATAAATCCAAAGAAACTAGAAATAATATTACTGACTTATCCGTAGAATCGCTTCGTAAGAGTTTAAAAAATGAT
TCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4MS74

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6HD92

References