Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 112364..113007 Replicon plasmid IncFIB/IncFIC
Accession NZ_CP117035
Organism Salmonella enterica strain PIW95_S14_0299

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag PQP07_RS26390 Protein ID WP_001044768.1
Coordinates 112591..113007 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag PQP07_RS26385 Protein ID WP_001261287.1
Coordinates 112364..112594 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP07_RS26360 (107604) 107604..108824 - 1221 WP_208217341.1 hypothetical protein -
PQP07_RS26370 (110209) 110209..110577 - 369 WP_243765465.1 hypothetical protein -
PQP07_RS26375 (110628) 110628..111458 - 831 WP_223201786.1 hypothetical protein -
PQP07_RS26380 (111510) 111510..112058 - 549 WP_039002808.1 hypothetical protein -
PQP07_RS26385 (112364) 112364..112594 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PQP07_RS26390 (112591) 112591..113007 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
PQP07_RS26395 (113169) 113169..115307 - 2139 WP_039002805.1 AAA family ATPase -
PQP07_RS26400 (115772) 115772..116767 + 996 WP_000246636.1 hypothetical protein -
PQP07_RS26405 (116810) 116810..117703 + 894 WP_001553853.1 S-4TM family putative pore-forming effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-Ia / tet(M) / dfrA12 / aadA2 / cmlA1 / ant(3'')-Ia / sul3 / mef(B) / blaTEM-1B - 1..133901 133901
- flank IS/Tn - - 117840..118217 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T269907 WP_001044768.1 NZ_CP117035:112591-113007 [Salmonella enterica]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT269907 WP_001261287.1 NZ_CP117035:112364-112594 [Salmonella enterica]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References