Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1772779..1773350 Replicon chromosome
Accession NC_017551
Organism Leptospira interrogans serovar Lai str. IPAV

Toxin (Protein)


Gene name mazF Uniprot ID Q8F5A3
Locus tag LIF_RS07605 Protein ID WP_000240418.1
Coordinates 1773009..1773350 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M6U553
Locus tag LIF_RS07600 Protein ID WP_000443825.1
Coordinates 1772779..1773015 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIF_RS07575 1769302..1769778 + 477 WP_000691822.1 hypothetical protein -
LIF_RS07580 1770027..1770230 - 204 WP_000532164.1 hypothetical protein -
LIF_RS07585 1770290..1770664 - 375 WP_001206461.1 hypothetical protein -
LIF_RS22825 1770669..1770934 - 266 Protein_1450 BrnT family toxin -
LIF_RS07590 1771046..1771339 + 294 WP_100220714.1 hypothetical protein -
LIF_RS07595 1771652..1772443 + 792 WP_000703027.1 hypothetical protein -
LIF_RS07600 1772779..1773015 + 237 WP_000443825.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LIF_RS07605 1773009..1773350 + 342 WP_000240418.1 endoribonuclease MazF Toxin
LIF_RS07610 1773418..1773800 - 383 Protein_1455 hypothetical protein -
LIF_RS07615 1773800..1774066 - 267 WP_000844450.1 hypothetical protein -
LIF_RS22830 1774127..1774455 - 329 Protein_1457 hypothetical protein -
LIF_RS07620 1774458..1775180 - 723 WP_000414906.1 hypothetical protein -
LIF_RS20995 1775393..1775599 + 207 WP_080010645.1 BrnT family toxin -
LIF_RS07630 1776328..1776789 + 462 WP_000811796.1 hypothetical protein -
LIF_RS07635 1777152..1777505 + 354 WP_002095367.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin

Antitoxin PemI-like

(1-78)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12918.12 Da        Isoelectric Point: 9.9595

>T26990 WP_000240418.1 NC_017551:1773009-1773350 [Leptospira interrogans serovar Lai str. IPAV]
MVKNRNYTPEKGDIVWLNFTPQAGHEQKGRRPALVLSPKEYNSKTGLAIFCPITSKIKGYPFEVLIKSKKIDGVILSDQV
KNLDWTIREAEFIESINKVSLKEVLDNIKLLIF

Download         Length: 342 bp

>T26990 NC_017551:1773009-1773350 [Leptospira interrogans serovar Lai str. IPAV]
TTGGTAAAGAATAGAAACTATACTCCTGAAAAAGGAGATATAGTGTGGTTGAACTTTACTCCTCAAGCAGGTCATGAACA
GAAAGGTCGTAGACCTGCACTTGTTTTATCGCCTAAGGAATATAATTCAAAGACAGGGTTAGCAATATTTTGTCCAATTA
CCAGTAAAATTAAAGGTTATCCATTCGAAGTGTTGATTAAATCAAAAAAAATCGATGGTGTAATTCTTTCTGATCAAGTA
AAAAACTTAGATTGGACTATCCGTGAAGCAGAATTTATTGAATCAATAAATAAAGTTTCTTTAAAAGAAGTTTTAGATAA
TATTAAATTATTAATATTCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8728.95 Da        Isoelectric Point: 5.6663

>AT26990 WP_000443825.1 NC_017551:1772779-1773015 [Leptospira interrogans serovar Lai str. IPAV]
MESIIQKWGNSLGIRIPKAMATELELNDGSHVELQYEGDKIVIYPMKKASLEDKLSKITKQNLHSEISTGNSIGNEAW

Download         Length: 237 bp

>AT26990 NC_017551:1772779-1773015 [Leptospira interrogans serovar Lai str. IPAV]
ATGGAATCAATTATTCAAAAATGGGGTAATAGCTTAGGAATTAGAATTCCAAAAGCAATGGCAACGGAATTAGAGTTAAA
TGATGGAAGCCATGTTGAATTACAATATGAAGGAGATAAGATTGTAATATATCCAATGAAAAAAGCTTCATTGGAAGATA
AACTTTCTAAAATTACGAAACAAAATCTTCACTCTGAAATATCTACTGGTAATTCTATAGGCAATGAAGCTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D8SL30

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6HC33

References