Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 88060..89683 Replicon plasmid IncHI2
Accession NZ_CP117034
Organism Salmonella enterica strain PIW95_S14_0299

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag PQP07_RS24955 Protein ID WP_000088046.1
Coordinates 88358..89683 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag PQP07_RS24950 Protein ID WP_024136327.1
Coordinates 88060..88353 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP07_RS24920 (PQP07_24930) 83932..85173 + 1242 WP_001053338.1 VWA domain-containing protein -
PQP07_RS24925 (PQP07_24935) 85264..85395 + 132 WP_000374059.1 hypothetical protein -
PQP07_RS24930 (PQP07_24940) 85736..86017 - 282 WP_000077926.1 hypothetical protein -
PQP07_RS24935 (PQP07_24945) 86067..86258 - 192 WP_000398480.1 hypothetical protein -
PQP07_RS24940 (PQP07_24950) 86350..86691 - 342 WP_001151575.1 hypothetical protein -
PQP07_RS24945 (PQP07_24955) 87025..87456 + 432 WP_011152969.1 hypothetical protein -
PQP07_RS24950 (PQP07_24960) 88060..88353 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
PQP07_RS24955 (PQP07_24965) 88358..89683 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
PQP07_RS24960 (PQP07_24970) 89744..89950 + 207 WP_000134171.1 hypothetical protein -
PQP07_RS24965 (PQP07_24975) 90052..90462 + 411 WP_000985911.1 hypothetical protein -
PQP07_RS24970 (PQP07_24980) 90475..91290 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
PQP07_RS24975 (PQP07_24985) 91544..91693 + 150 WP_156839068.1 hypothetical protein -
PQP07_RS24980 (PQP07_24990) 91722..92419 + 698 WP_095033700.1 IS1-like element IS1B family transposase -
PQP07_RS24985 (PQP07_24995) 92578..93243 - 666 WP_000490638.1 hypothetical protein -
PQP07_RS24990 (PQP07_25000) 93301..93681 - 381 WP_001426317.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / mcr-1.1 - 1..232119 232119
- flank IS/Tn - - 91722..91997 275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T269898 WP_000088046.1 NZ_CP117034:88358-89683 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT269898 WP_024136327.1 NZ_CP117034:88060-88353 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References