Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4480845..4481626 Replicon chromosome
Accession NZ_CP117033
Organism Salmonella enterica strain PIW95_S14_0299

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag PQP07_RS22135 Protein ID WP_000626099.1
Coordinates 4480845..4481336 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag PQP07_RS22140 Protein ID WP_001110452.1
Coordinates 4481333..4481626 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP07_RS22095 (4476031) 4476031..4476273 - 243 WP_197603740.1 hypothetical protein -
PQP07_RS22100 (4476270) 4476270..4476626 - 357 WP_033567083.1 hypothetical protein -
PQP07_RS22105 (4476623) 4476623..4477495 - 873 WP_033567082.1 ParA family protein -
PQP07_RS22110 (4477686) 4477686..4477763 - 78 Protein_4327 helix-turn-helix domain-containing protein -
PQP07_RS22115 (4477854) 4477854..4478186 - 333 WP_001165471.1 MerR family transcriptional regulator -
PQP07_RS22120 (4478258) 4478258..4478635 + 378 WP_000916345.1 EthD family reductase -
PQP07_RS22125 (4479668) 4479668..4479742 + 75 Protein_4330 porin family protein -
PQP07_RS22130 (4479845) 4479845..4480597 + 753 WP_000842434.1 non-specific acid phosphatase -
PQP07_RS22135 (4480845) 4480845..4481336 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
PQP07_RS22140 (4481333) 4481333..4481626 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
PQP07_RS22145 (4481943) 4481943..4482164 + 222 WP_001576552.1 hypothetical protein -
PQP07_RS22150 (4482429) 4482429..4483304 + 876 WP_000921674.1 AraC family transcriptional regulator -
PQP07_RS22155 (4483301) 4483301..4483588 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQP07_RS22160 (4483611) 4483611..4483826 + 216 WP_001595136.1 hypothetical protein -
PQP07_RS22165 (4483834) 4483834..4484103 + 270 WP_010989096.1 hypothetical protein -
PQP07_RS22170 (4484397) 4484397..4485302 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T269895 WP_000626099.1 NZ_CP117033:c4481336-4480845 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT269895 WP_001110452.1 NZ_CP117033:c4481626-4481333 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References